新辅助放化疗对食管癌术后ki-67、CD44v6及PD-1/PD-L1表达的影响  

The Effect of Neoadjuvant Radiotherapy and Chemotherapy on the Expression of ki-67, CD44v6, and PD-1/PD-L1 after Esophageal Cancer Surgery

作　　者：巩想平 史永铁 GONG Xiangping;SHI Yongtie(Department of Gastroenterology,Baoji High-tech Hospital,Baoji Shaanxi 721000)

机构地区：[1]宝鸡高新医院消化内科,陕西宝鸡721000 [2]陕西省扶风县人民医院肿瘤放疗科,陕西宝鸡722299

出　　处：《医学临床研究》2023年第12期1892-1894,1898,共4页Journal of Clinical Research

摘　　要：【目的】探讨新辅助放化疗对食管癌患者术后细胞核蛋白(ki-67)、整合膜糖蛋白(CD44v6)及程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡蛋白配体1(PD-L1)表达的影响。【方法】76例食管癌患者随机分为观察组和对照组,每组38例。两组患者均行常规食管癌根治术,观察组患者在术前行新辅助放化疗治疗。比较两组患者围术期指标、临床疗效、术后ki-67、CD44v6、PD-1/PD-L1表达水平及并发症发生率。【结果】两组患者术中出血量、手术时间、胸液量比较,差异均无统计学意义(P>0.05);观察组住院天数少于对照组(P<0.05)。观察组患者客观有效率为76.32%(29/38),显著高于对照组的52.63%(20/38)(P<0.05)。观察组患者术后ki-67蛋白阳性表达率和CD44v6、PD-1/PD-L1水平均低于对照组(P<0.05)。两组患者并发症总发生率比较,差异无统计学意义(P>0.05)。【结论】术前新辅助放化疗能够有效提高食管癌患者的临床疗效和免疫功能,且安全性较高。【Objective】To explore the effects of neoadjuvant radiotherapy and chemotherapy on the expression of nuclear protein(ki-67),integrated membrane glycoprotein(CD44v6),and programmed cell death protein-1(PD-1)/programmed cell death protein ligand 1(PD-L1)in postoperative esophageal cancer patients.【Method】A total of 76 patients with esophageal cancer were randomly divided into an observation group and a control group,with 38 cases in each group.Both groups of patients underwent routine esophageal cancer radical surgery,while the observation group received neoadjuvant chemotherapy before surgery.We compared perioperative indicators,clinical efficacy,postoperative ki-67,CD44v6,PD-1/PD-L1 expression levels,and incidence of complications between two groups of patients.【Results】There was no statistically significant difference in intraoperative bleeding,surgical time,and pleural fluid volume between the two groups of patients(P>0.05);The length of hospital stay in the observation group was less than that in the control group(P<0.05).The objective effective rate of the observation group patients was 76.32%(29/38),significantly higher than the control group's 52.63%(20/38)(P<0.05).The positive expression rate of ki-67 protein and the levels of CD44v6 and PD-1/PD-L1 in the observation group were lower than those in the control group after surgery(P<0.05).There was no statistically significant difference in the total incidence of complications between the two groups of patients(P>0.05).【Conclusion】Preoperative neoadjuvant radiotherapy and chemotherapy can effectively improve the clinical efficacy and immune function of esophageal cancer patients,with high safety.

关 键 词：食管肿瘤/外科学 食管肿瘤/放射疗法 食管肿瘤/药物疗法 KI-67抗原 透明质酸受体 

分 类 号：R735.1[医药卫生—肿瘤]