轮状病毒肠炎患儿心肌损伤标志物及T淋巴细胞亚群水平观察  

Observation of Myocardial Injury Markers and T Lymphocyte Subsets in Children with Rotavirus Enteritis

作　　者：张晓梅 赵云爱 ZHANG Xiaomei;ZHAO Yunai(Shenmu Hospital,Shenmu Shaanxi 719300)

机构地区：[1]神木市医院,陕西神木719300

出　　处：《医学临床研究》2023年第12期1926-1928,1932,共4页Journal of Clinical Research

摘　　要：【目的】探讨轮状病毒肠炎患儿心肌损伤、T淋巴细胞的变化情况及其相关性。【方法】回顾性分析2019年1月至2022年1月本院收治的80例轮状病毒肠炎患儿(观察组),根据脱水严重程度将观察组分为无脱水组(n=26)、轻度组(n=32)及中度组(n=22)。另选取同期本院收治的轮状病毒检测阴性的80例肠炎患儿作为对照组。比较两组及不同脱水程度病例组间心肌损伤标志物[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟基丁酸脱氢酶(α-HBDH)]水平和T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+),并计算出CD4^(+)/CD8^(+)值)。【结果】观察组CK、CK-MB、LDH、α-HBDH水平显著高于对照组,差异有统计学意义(P<0.05)。轻度组、中度组患儿CK、CK-MB、LDH、α-HBDH水平高于无脱水组,中度组患儿高于轻度组,差异有统计学意义(P<0.05)。观察组CD8^(+)高于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)值低于对照组,差异有统计学意义(P<0.05)。轻度组、中度组患儿CD8^(+)高于无脱水组患儿,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平低于无脱水组,且轻度组上述指标与中度组比较,差异均有统计学意义(P<0.05)。【结论】心肌损伤标志物及T淋巴细胞亚群可以较准确评估轮状早期病毒性肠炎患儿脱水情况,对指导临床后期治疗具有重要意义。【Objective】To explore the myocardial injury and changes in T lymphocytes in children with rotavirus enteritis and their correlation.【Methods】A retrospective analysis was conducted on 80 children with rotavirus enteritis admitted to our hospital from January 2019 to January 2022(observation group).According to the severity of dehydration,the observation group was divided into non dehydration group(n=26),mild dehydration group(n=32),and moderate dehydration group(n=22).Another 80 children with enteritis who tested negative for rotavirus and were admitted to our hospital during the same period were selected as the control group.Myocardial injury biomarkers between two groups and cases with different degrees of dehydration[Creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBDH)]levels and T lymphocyte subpopulations(CD3^(+),CD4^(+),CD8^(+),and calculate the CD4^(+)/CD8^(+)ratio)were compared.【Results】The levels of CK,CK-MB,LDH,andα-HBDH in the observation group were significantly higher than those in the control group,with statistical significance(P<0.05).The levels of CK,CK-MB,LDH,andα-HBDH in the mild and moderate groups of children were higher than those in the non dehydration group,while those in the moderate group were higher than those in the mild group,with statistical significance(P<0.05).The CD8^(+)in the observation group was higher than that in the control group,and the CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)values were lower than those in the control group,with statistical significance(P<0.05).The CD8^(+)levels in the mild and moderate groups were higher than those in the non dehydrated group,and the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)were lower than those in the non dehydrated group.Moreover,the above indicators in the mild group were significantly different from those in the moderate group(P<0.05).【Conclusion】Myocardial injury markers and T lymphocyte subsets can accurately evaluate the dehydration status of childr

关 键 词：肠炎/病毒学 轮状病毒感染 T淋巴细胞亚群 心肌 

分 类 号：R574.62[医药卫生—消化系统]