Clock gene Per3 deficiency disrupts circadian alterations of gut microbiota in mice  

作　　者：Xiaoxian Xie Haoshen Xu Ruonan Shu Lei Sun Mengya Zhang Qinglian Hu Kai Zhu Zezhi Li Fengchun Wu 

机构地区：[1]College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310032,China [2]Department of Psychiatry,the Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China [3]Shanghai Mental Health Center,Shanghai Jiao Tong University,School of Medicine,Shanghai 201109,China [4]Department of Pharmacology,University of Oxford,Mansfield Road,OX13QT Oxford,UK [5]College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第12期2004-2007,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China (No.31701028);the Zhejiang Provincial Natural Science Foundation of China (No.LY20C110002).

摘　　要：Circadian rhythms are present in all organisms.The endogenous circadian clock is an autonomous temporal system that generates a rhythm of approximately 24 h even in the absence of environmental signals.The"core"genes in the circadian clock system of mammals consist of Clock and Bmall,which generate activators,along with Cryl,Cry2,Per1 and Per2,which generate repressors.

关 键 词：alterations PER1 ENDOGENOUS 

分 类 号：R574[医药卫生—消化系统]