Wnt/β-catenin信号通路介导胶质瘤上皮间质转化的研究进展  

Research progress on Wnt/β-catenin signaling pathway-mediated epithelialmesenchymal transition in glioma

作　　者：祁洲 田国鹏 袁国强[1,2] 潘亚文 QI Zhou;TIAN Guopeng;YUAN Guoqiang;PAN Yawen(Department of Neurosurgery,Lanzhou University Second Hospital,Lanzhou,Gansu 730030,China;Key Laboratory of Neurology of Gansu Province,Lanzhou,Gansu 730030,China)

机构地区：[1]兰州大学第二医院神经外科,甘肃兰州730030 [2]甘肃省神经病学重点实验室,甘肃兰州730030

出　　处：《国际神经病学神经外科学杂志》2023年第6期78-83,共6页Journal of International Neurology and Neurosurgery

基　　金：国家自然科学基金(82060455);兰州大学第二医院萃英学子科研培育计划(CYXZ2022-14)。

摘　　要：胶质母细胞瘤是中枢神经系统中一种具有高度侵袭性的恶性肿瘤,其发病机制尚不明确,且缺乏特异性的诊疗措施,病死率仍然居高不下。因此,亟须探索胶质瘤扩散、浸润的机制和开发新型治疗措施。上皮间质转化(EMT)在胶质瘤扩散、浸润的调控中发挥关键作用,已被证实与胶质瘤侵袭、迁移和治疗抵抗有关,而Wnt/β-catenin信号通路可介导EMT参与人体多种病理生理过程,此外,微小RNA可以与EMT相互作用进而影响细胞的生物学行为。该文通过综述Wnt/β-catenin信号通路对胶质瘤EMT的影响及针对该进程不同的干预措施,为该领域的研究提供参考。Glioblastoma is a highly aggressive malignant tumor in the central nervous system with an extremely poor prognosis.The pathogenesis of this disease is not fully understood and the mortality remains high due to the lack of specific diagnosis and treatment methods.Therefore,it is urgent to explore the mechanism of glioma spread and infiltration and develop novel treatments.Epithelial-mesenchymal transition(EMT)plays a key role in regulating the spread and infiltration of glioma,and has been proven to be associated with glioma invasion,migration,and therapeutic resistance.The Wnt/β-catenin signaling pathway can play a role in a range of pathophysiological processes via EMT.Furthermore,microRNAs can interact with EMT and influence cellular processes.This article reviews the effects of the Wnt/β-catenin signaling pathway on glioma EMT and different interventions for this process,providing theoretical basis and reference for preventing the EMT in glioma.

关 键 词：神经胶质瘤 上皮间质转化 WNT/Β-CATENIN信号通路 作用机制 

分 类 号：R739.41[医药卫生—肿瘤]