^(18)F-FET PET在成人高级别胶质瘤诊治中的应用新进展  

New Advances in the Use of ^(18)F⁃FET PET in the Diagnosis and Management of Adult High⁃Grade Gliomas

作　　者：韩青青 李拓 邢海群[1] 任超[1] 刘家惠 王裕[2] 马文斌[2] 程欣[1] 霍力[1,3] HAN Qingqing;LI Tuo;XING Haiqun;REN Chao;LIU Jiahui;WANG Yu;MA Wenbin;CHENG Xin;HUO Li(Department of Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Neurosurgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院核医学科,北京100730 [2]中国医学科学院北京协和医院神经外科,北京100730 [3]中国医学科学院北京协和医院核医学分子靶向诊疗北京市重点实验室,北京100730

出　　处：《罕见病研究》2024年第1期102-107,共6页Journal of Rare Diseases

基　　金：中央高水平医院临床科研业务费(2022-PUMCH-A-019)。

摘　　要：胶质瘤是成人最常见的原发性颅内肿瘤,其中高级别胶质瘤患者具有生存期短、预后差的特点。高级别胶质瘤的诊断、治疗、疗效评价及预后预测对于改善患者生存有着重要意义。传统增强磁共振成像在定义肿瘤边界、鉴别肿瘤进展与治疗相关改变等方面存在着不足,因此,将氨基酸PET尤其是^(18)F-FET PET纳入高级别胶质瘤的诊治过程已得到广泛共识。本文对近年来^(18)F-FET PET在成人高级别胶质瘤的诊断、治疗中的研究新进展进行阐述。Gliomas are the most common primary intracranial tumors in adults,among which high-grade glioma patients are characterized by short survival and poor prognosis.The diagnosis,treatment,evaluation of effective treatments,and prognosis prediction of high-grade gliomas are of great significance for improving pa-tient survival.Conventional enhanced magnetic resonance imaging has deficiencies in delineating tumor extent,identifying tumor progression and treatment-related changes.Therefore,there is a broad consensus to incorporate amino acid PET,and ^(18)F-FET PET inparticular,into the diagnostic and therapeutic process of high-grade gliomas.In this article,we review the new research progress of ^(18)F-FET PET in the diagnosis and treat-ment of adult high-grade glioma in recent years.

关 键 词：^(18)F-FET PET 高级别胶质瘤 磁共振成像 罕见病 

分 类 号：R817[医药卫生—影像医学与核医学]