巨噬细胞在原发性胆汁性胆管炎发病中的作用机制及影响  

The role and impact of macrophages in the pathogenesis of primary biliary cholangitis

作　　者：马狄 邰文琳[1] MA Di;TAI Wenlin(Department of Clinical Laboratory,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院检验科,昆明650101

出　　处：《临床肝胆病杂志》2024年第1期157-160,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82060385);昆明医科大学2023年研究生创新基金(2023S321)。

摘　　要：原发性胆汁性胆管炎(PBC)是一种以肝内胆汁淤积为特征表现的慢性自身免疫性疾病,免疫因素导致进行性小胆管破坏,胆汁淤积,最终发展为肝纤维化、肝硬化甚至肝衰竭。巨噬细胞作为一群具有功能异质性的群体,在PBC整个疾病进程中发挥着不同的作用。本文归纳了巨噬细胞参与PBC发病机制的可能方式,讨论了其对PBC的影响及相关潜在治疗靶点。本文指出巨噬细胞主要参与了PBC损伤中的先天性免疫,且与肠道微生物失调相联系,在疾病后期与胆汁淤积、肝纤维化、肝硬化有关。Primary biliary cholangitis(PBC)is a chronic autoimmune disease of cholestasis in which immune factors lead to progressive small bile duct destruction,cholestasis,and eventually liver fibrosis,liver cirrhosis,and even liver failure.Macrophages,as a group with functional heterogeneity,play different roles in the whole disease process of PBC.This article summarizes the possible ways by which macrophages are involved in the pathogenesis of PBC and discusses their impact on the disease and the potential therapeutic targets of macrophages.It is pointed out that macrophages are mainly involved in innate immunity in PBC injury and are associated with gut microbiota dysbiosis,and they are also associated with cholestasis,liver fibrosis,and liver cirrhosis in the later stages of the disease.

关 键 词：原发性胆汁性胆管炎 巨噬细胞 病理过程 

分 类 号：R575.7[医药卫生—消化系统]