顶端钠依赖性胆汁酸转运蛋白(ASBT)在肝胆疾病中的作用  

Role of apical sodium-dependent bile acid transporter in hepatobiliary diseases

作　　者：谢晓暄 杜丽娜[1] 郭紫云 杨燕[1] XIE Xiaoxuan;DU Lina;GUO Ziyun;YANG Yan(Department of Traditional Chinese Medicine,National Center for Children’s Health,Beijing Children’s Hospital,Capital Medical University,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院中医科,北京100045

出　　处：《临床肝胆病杂志》2024年第1期199-203,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82205184);北京市属医院科研培育计划(PZ2022027)。

摘　　要：顶端钠依赖性胆汁酸转运蛋白(ASBT)是负责胆汁酸肠道重吸收的关键转运体,对维持胆汁酸和胆固醇稳态起重要作用,其表达受到转录因子、核受体和肠道微生物等多种因素的调控。ASBT的表达和功能异常会导致胆汁酸及胆固醇代谢紊乱,引起多种肝胆相关疾病。目前,ASBT作为一种治疗靶点已受到广泛关注。本文阐述了ASBT的生物学特征及表达调控机制,并对ASBT在肝胆疾病中的作用进行了综述,为相关疾病的治疗提供新方向。Apical sodium-dependent bile acid transporter(ASBT)is a key transporter responsible for intestinal reabsorption of bile acid and plays an important role in maintaining bile acid and cholesterol homeostasis,and its expression is regulated by various factors including transcription factors,nuclear receptors,and intestinal microflora.The abnormal expression and function of ASBT can lead to disorders in the metabolism of bile acid and cholesterol,causing a variety of hepatobiliary diseases.At present,ASBT has attracted wide attention as a therapeutic target.This article elaborates on the biological characteristics and expression regulation mechanism of ASBT and reviews the role of ASBT in hepatobiliary diseases,in order to provide a new direction for the treatment of related diseases.

关 键 词：顶端钠依赖性胆汁酸转运蛋白 胆汁酸类 胆汁淤积 

分 类 号：R575[医药卫生—消化系统]