生物导向型牙体预备技术对修复体边缘牙周菌斑定植水平和龈沟液炎症因子水平的影响  

The effects of biologically oriented preparation technique on periodontal plaque colonization and inflammatory factor expression in gingival crevicular fluid

作　　者：徐启蒙 蒋升 XU Qimeng;JIANG Sheng(Department of Stomatology,Suzhou Hospital,Nanjing Medical University,China,215026)

机构地区：[1]南京医科大学附属苏州医院口腔科,215026

出　　处：《实用口腔医学杂志》2024年第1期91-96,共6页Journal of Practical Stomatology

摘　　要：目的:探讨运用生物导向型预备技术制备的修复体边缘牙周菌斑定植和龈沟液(GCF)炎症因子水平及临床意义。方法:纳入102例慢性牙周炎患者,随机分为2组(n=51),对照组行传统牙体预备,观察组行生物导向性预备技术。比较两组患者术前和术后6月修复体边缘骨吸收量、探诊方面的具体深度、牙龈乳头以及改良菌斑方面的具体指数、改良龈沟出血指数,在修复体位置采集龈沟液,测定TNF-α、 IL-6和MMP8水平。结果:术后6月观察组和对照组患者近中、远中及平均骨吸收量差异无统计学意义(P>0.05)。两组患者修复体牙周指数明显降低(P<0.05),且观察组患者改良龈沟出血指数、探诊深度、牙龈乳头指数和改良菌斑指数明显低于对照组(P<0.05)。两组患者龈沟液炎性因子明显降低,且观察组患者TNF-α、MMP8和IL-6明显低于对照组(P<0.05)。观察组患者舒适度、固位功能、美观度和总分明显高于对照组(P<0.05),而在咀嚼功能、语言功能方面差异未见统计学意义(P>0.05)。结论:生物导向性预备技术应用于慢性牙周炎患者,可有效改善修复体定植水平,消除龈沟液炎症反应,提高患者满意度。Objective:To study the effects of biologically oriented preparation technique(BOPT)on periodontal plaque colonization and inflammatory factor expression in gingival crevicular fluid(GCF).Methods:102 patients with chronic periodontitis were randomly divided into 2 groups(n=51).The subjects in control group received traditional tooth preparation,while those in observation group received BOPT.The probing depth,modified plaque index,gum papillary index,marginal bone resorption and modified gingival groove bleeding index were measured and compared between the 2 groups.The GCF was collected at the restoration site before and after 6 month restoration,the levels of tumor necrosis factor-α,interleukin-6 and matrix metalloproteinase 8 were measured at different time periods.Results:6 months after surgery,there was no significant difference in near-middle,far-middle and mean bone resorption between the 2 groups(P>0.05).The restoration periodental indexes were decreased in both groups(P<0.05),and the modified gingival hemorrhage index,probing depth,gum papilla index and modified plaque index in the observation group were obvious lower than in the control(P<0.05).The inflammatory factor expression in GCF was significantly decreased in both groups(P<0.05),and in the observation group was obvious lower than in the control(P<0.05).Patient comfort,retention function,aesthetics and total score in the observation group was obvious higher than in the control(P<0.05),but there was no statistically significant difference in chewing function,language function between the 2 groups(P>0.05).Conclusion:BOPT may improve the restoration level,eliminate the inflammatory response of GCF and improve satisfaction in patients with chronic periodontitis.

关 键 词：生物导向性预备技术 固定义齿修复 慢性牙周炎 炎症因子 

分 类 号：R781.4[医药卫生—口腔医学]