疣状表皮发育不良伴发肿瘤的临床特点分析  

Analysis of Clinical Characteristics of Epidermodysplasia Verruciformis Accompanied by Tumors

作　　者：束敏 郝阳阳 闫媛媛 Shu Min;Hao Yangyang;Yan Yuanyuan(Kangda College of Nanjing Medical University,Lianyungang,Jiangsu 222000;The First People’s Hospital of Huzhou,Huzhou,Zhejiang 313000)

机构地区：[1]南京医科大学康达学院,江苏连云港222000 [2]湖州市第一人民医院,浙江湖州313000

出　　处：《科技与健康》2024年第1期13-16,共4页Technology and Health

基　　金：湖州市科技局项目(2021GYB52)。

摘　　要：为了解疣状表皮发育不良患者伴发肿瘤的性质和临床特点,检索近20年来文献发表的31例具有详细疣状表皮发育不良确诊肿瘤患者,分析疣状表皮发育不良患者不同肿瘤性质组成及临床特点。结果显示,①疣状表皮发育不良患者可伴发鳞状细胞癌(SCC)、基底细胞癌(BCC)、鳞状腺癌(SEC)、Merkel细胞癌(MCC)或鳞状细胞癌合并基底细胞癌;②疣状表皮发育不良伴发肿瘤患者中,以鳞状细胞癌居多,占所有患者的51.6%。扁平疣型疣状表皮发育不良患者伴发肿瘤更为常见,占所有疣状表皮发育不良患者的77.4%;③肿瘤多发于皮肤暴露部位,头面部20例(64.5%)、躯干10例(32.3%)及口腔、生殖器黏膜1例(3.2%);④发病年龄多集中在幼年,其中15例患者在幼儿期(0~6岁)出现皮损等症状,8例患者在少儿期(7~12岁)出现症状;4例患者为青少年(13~17岁);4例患者为青年(18~45岁)。肿瘤发生的年龄在疣状表皮发育不良后20~40年的有27例(87.1%)。⑤男性患者更易伴发肿瘤,占74.2%。研究发现,疣状表皮发育不良患者伴发肿瘤以鳞状细胞癌多发。To understand the nature and clinical characteristics of tumors in patients with EV,31 confirmed tumor patients with detailed EV published in literature in the past 20 years were searched,and the different tumor properties and clinical characteristics of patients with EV were analyzed.The results showed that①patients with EV may be accompanied by squamous cell carcinoma(SCC),basal cell carcinoma(BCC),squamous adenocarcinoma(SEC),Merkel cell carcinoma(MCC),or squamous cell carcinoma with basal cell carcinoma;②Among patients with EV accompanied by tumors,squamous cell carcinoma is the most common,accounting for 51.6%of all patients.Flat wart type EV patients with accompanying tumors are more common,accounting for 77.4%of all patients with EV;③Tumors are more common in exposed skin areas,with 20 cases(64.5%)on the head and face,10 cases(32.3%)on the trunk,and 1 case(3.2%)on the oral and genital mucosa.④The onset age is mostly concentrated in childhood,with 15 patients experiencing symptoms such as skin lesions in early childhood(0-6 years old)and 8 patients experiencing symptoms in childhood(7-12 years old);Four patients were adolescents(aged 13-17);Four patients were young adults(aged 18-45).27 cases(87.1%)of tumors occurred 20-40 years after the development of EV.⑤Male patients are more prone to developing tumors,accounting for 74.2%.Research has found that patients with EV are often accompanied by squamous cell carcinoma.

关 键 词：疣状表皮发育不良 肿瘤 鳞状细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]