抗炎免疫疗法在发热感染相关性癫痫综合征中应用进展  

Anti-inflammatory immunotherapy in febrile infection-associated epilepsy syndrome

作　　者：王博[1] 邓会芳 孙婧 王钦鹏[1] 苏丹丹[1] 梁成[1] WANG Bo;DENG Huifang;SUN Jing;WANG Qingpeng;SU Dandan;LIANG Cheng(Lanzhou University Second Hospital,Lanzhou 730030,China.)

机构地区：[1]兰州大学第二医院神经内科ICU,兰州730030

出　　处：《中国神经精神疾病杂志》2023年第11期695-699,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：甘肃省自然科学基金(编号:2021-0405-JCC-1549)。

摘　　要：发热感染相关性癫痫综合征(febrile infection-related epilepsy syndrome,FIRES)是一种以难治性癫痫持续状态为主要表现的致死性脑病,选择有效的抗癫痫药物(antiepileptic drugs,AEDs)是治疗的重点和难点。本文总结了不同抗炎免疫疗法在该病治疗中的作用机制、用药方法和不良反应,发现早期开始生酮饮食(ketogenic diet,KD)是目前最有效的治疗方法之一,尚需进一步研究以明确药物不良反应及不同药物联用的效果。Febrile infection-related epilepsy syndrome(FIRES)is a lethal encephalopathy with refractory status epilepticus as the main manifestation,and the selection of effective antiepileptic drugs(AEDs)is the focus and difficulty of treatment.This review summarises the mechanism of action,drug administration and adverse effects of different antiinflammatory immunotherapies in the treatment of this disease,and finds that early initiation of ketogenic diet(KD)is one of the most effective treatments at present,and further studies are needed to clarify the adverse effects of the drugs and the effects of the combination of different drugs.

关 键 词：发热感染相关性癫痫综合征 难治性癫痫持续状态 抗炎免疫疗法 阿那白滞素 生酮饮食 大麻二酚 

分 类 号：R742[医药卫生—神经病学与精神病学]