胃溃疡应用奥美拉唑联合阿莫西林治疗的效果观察  

Observation on effect of omeprazole combined with amoxicillin in treatment of gastric ulcer

作　　者：刘长红 LIU Chang-hong(Huanren Manchu Autonomous County Hospital of Traditional Chinese Medicine,Benxi 117200,China)

机构地区：[1]辽宁省本溪市桓仁满族自治县中医院,117200

出　　处：《中国现代药物应用》2023年第24期114-117,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 观察胃溃疡应用奥美拉唑联合阿莫西林治疗的效果。方法 116例胃溃疡患者,采用抽签方法分为治疗组和对比组,每组58例。治疗组采用奥美拉唑联合阿莫西林治疗,对比组采用阿莫西林联合法莫替丁治疗。比较两组患者治疗前后的胃肠激素[胃泌素(GAS)、胃动素(MTL)]及血清炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,疗效,用药后不良反应发生情况。结果 治疗后,两组患者的GAS水平均低于本组治疗前、MTL水平均高于本组治疗前,且治疗组患者的GAS(70.16±5.64)ng/L低于对比组的(81.27±7.62)ng/L、MTL(240.09±22.68)ng/L高于对比组的(215.27±19.26)ng/L,差异具有统计学意义(P<0.05)。治疗后,两组患者的CRP、IL-6水平均低于本组治疗前,且治疗组患者的CRP(3.26±0.84)mg/L、IL-6(30.89±3.74)ng/L均低于对比组的(6.12±1.22)mg/L、(42.35±5.73)ng/L,差异具有统计学意义(P<0.05)。治疗组患者的总有效率96.55%高于对比组的84.48%,差异具有统计学意义(P<0.05)。两组患者用药后不良反应发生率比较,差异无统计学意义(P>0.05)。结论 胃溃疡采用奥美拉唑和阿莫西林联合治疗的方案可明显改善患者的胃肠激素水平和炎性因子水平,提高治疗效果,对患者的良好预后有重要意义。Objective To observe the effect of omeprazole combined with amoxicillin in treatment of gastric ulcer.Methods A total of 116 patients with gastric ulcer were divided into a treatment group and a comparison group by lottery method,with 58 cases in each group.The treatment group was treated with omeprazole and amoxicillin,and the comparison group was treated with amoxicillin and famotidine.Both groups were compared in terms of levels of gastrointestinal hormones[gastrin(GAS),motilin(MTL)]and serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)]before and after treatment,the efficacy,and the occurrence of adverse reactions after medication.Results After treatment,GAS level in both groups were lower than that before treatment in this group,and MTL level was higher than that before treatment in this group;GAS of(70.16±5.64)ng/L in the treatment group was lower than that of(81.27±7.62)ng/L in the control group;MTL of(240.09±22.68)ng/L in the treatment group was higher than that of(215.27±19.26)ng/L in the control group;the differences were statistically significant(P<0.05).After treatment,the levels of CRP and IL-6 in both groups were lower than those before treatment in this group;CRP of(3.26±0.84)mg/L and IL-6 of(30.89±3.74)ng/L in the treatment group were lower than those of(6.12±1.22)mg/L and(42.35±5.73)ng/L in the control group;the differences were statistically significant (P<0.05). The total effective rate of 96.55% in the treatment group was higher than that of 84.48% in the comparison group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions after medication between the two groups (P>0.05). Conclusion The combination therapy of omeprazole and amoxicillin can significantly improve the levels of gastrointestinal hormones and inflammatory factors in patients with gastric ulcer, and improve the therapeutic effect of the disease, which is of great significance for the good prognosis of patients.

关 键 词：胃溃疡 奥美拉唑 阿莫西林 临床疗效 不良反应 

分 类 号：R573.1[医药卫生—消化系统]