慢性精神分裂症患者症状波动与患者外周血细胞计数水平相关性研究  

Study on the Relationship Between the Fluctuation of Symptoms and the Level of Peripheral Complete Blood Count in Sluggishly Progressing Schizophrenia Patients

作　　者：朱烨青 苏志斌 官廖昊 ZHU Yeqing;SU Zhibin;GUAN Liaohao(Xiamen Xianyue Hospital,Xianyue Hospital Affiliated with Xiamen Medical College,Fujian Psychiatric Center,Fujian Clinical Research Center for Mental Disorders,Xiamen 361012,China)

机构地区：[1]厦门市仙岳医院,厦门医学院附属仙岳医院,福建省精神医学中心,福建省精神疾病临床医学研究中心,厦门361012

出　　处：《中国医药指南》2024年第3期1-4,共4页Guide of China Medicine

基　　金：动态炎性标记物预警慢性精神分裂症疾病波动临界状态的研究(项目编号:3502Z20224ZD1320)。

摘　　要：目的 探讨慢性精神分裂症患者外周血细胞计数水平及其与临床症状波动之间的相关性。方法 纳入2022年1月于我院精神科长期住院的慢性精神分裂症患者200例。进行半年的动态随访观察,所有受试者入组后进行一次阳性与阴性症状量表(PANSS)评估临床症状及一次血常规检测后进入观察期,观察期间每2周进行一次PANSS评估、每4周进行一次血常规检测,期间若病情波动则被划分为病情波动组并终止观察、半年未波动则为未波动组,比较两组PANSS及血常规指标。结果 通过观察得到病情波动组人数为86例,病情未波动组为114例;病情波动组阳性症状及兴奋评分均高于病情未波动组;病情波动组MON、WBC、NEU、LYM均高于病情未波动组,NLR、SIII均高于病情未波动组,PLT、PLR均低于病情未波动组,以上差异均无统计学意义(P> 0.05);通过比较同一患者波动期NLR、PLR、MLR值均高于同一患者稳定期。此外,波动期患者白细胞计数(WBC)、中性粒细胞(NEU)、血小板(PLT)、单核细胞计数(MON)均高于稳定期。在淋巴细胞计数方面,波动期和稳定期无显著差异。病情波动组阳性症状及兴奋评分与PLR、SIII呈正相关(P <0.05)。结论 慢性精神分裂症患者阳性症状、兴奋症状波动存在炎症紊乱,WBC、NEU、SIII可作为慢性精神分裂症症状波动预测因子。Objective To investigate the correlation between peripheral blood cell count level and clinical symptom fluctuation in patients with chronic schizophrenia.Methods A total of 200 patients with chronic schizophrenia who were hospitalized for a long time in the psychiatric department of our hospital in January 2022 were included.Dynamic follow-up was conducted for a total of six months.All subjects were enrolled in the observation period after a positive and negative Symptom scale(PANSS)assessment of clinical symptoms and a routine blood test.During the observation period,PANSS assessment was performed every 2 weeks and routine blood test was performed every 4 weeks.If the disease condition fluctuated during the period,the patients were divided into the disease condition fluctuation group and the patients with no fluctuation for half a year were divided into the non-fluctuation group.PANSS and blood routine indexes of the two groups were compared.Results There were 86 patients in the group with fluctuating condition and 114 in the group without fluctuating condition.The positive symptoms and excitability scores of patients with fluctuating disease were higher than those of patients without fluctuating disease.WBC,NEU,LYM and MON of the disease fluctuation group were higher than those of the group without disease fluctuation;NLR and SIII were higher than those of the group without disease fluctuation;PLT and PLR were lower than those in the group without disease fluctuation,and the differences were not statistically significant(P>0.05).The NLR,PLR and MLR values in the fluctuating period were higher than those in the stable period in the same patient.In addition,the white blood cell count(WBC),neutrophil(NEU),platelet(PLT)and monocyte count(MON)in the fluctuating stage were higher than those in the stable stage.There was no significant difference in lymphocyte count between the fluctuating period and the stable period.The positive symptoms and excitability scores in the disease fluctuation group were positively corre

关 键 词：慢性精神分裂症 血细胞计数 炎性指标 症状波动 

分 类 号：R749.3[医药卫生—神经病学与精神病学]