IV型胶原蛋白相关听力损失的研究进展  

Research Progress on Type IV Collagen-Related Hearing Loss

作　　者：杨金源 袁永一[1] YANG Jinyuan;YUAN Yongyi(Department of Otolaryngology-Head&Neck Surgery/PLA Institute of Otolaryngology,PLA General Hospital,National Clinical Research Center for Otolaryngologic Diseases,Key Lab of Hearing Science,Ministry of Education,Beijing Key Lab of Hearing Impairment Prevention and Treatment,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院耳鼻咽喉头颈外科、解放军耳鼻咽喉研究所、国家耳鼻咽喉疾病临床医学研究中心、聋病教育部重点实验室、聋病防治北京市重点实验室,北京100853

出　　处：《中华耳科学杂志》2023年第5期706-710,共5页Chinese Journal of Otology

基　　金：国家重点研发计划(2016YFC1000704,2016YFC1000706);国家自然科学基金(81873704)。

摘　　要：IV型胶原蛋白是基底膜等组织的重要组成成分,广泛存在于肾脏、耳蜗等人体器官中。相比引起如肾脏等器官的疾病而言,国内外研究对IV型胶原蛋白相关听力损失的关注相对较少。本文旨在总结已报道的部分IV型胶原蛋白亚型与听力损失相关疾病的研究进展,为后续相关研究提供研究方向参考。Type IV collagen is an important component of the basement membrane and in other tissues,widely present in human organs such as the kidney and cochlea.Compared with type IV collagen-related issues in kidney diseases,researches in China and abroad have paid less attention to its roles in hearing loss.This article aims to summarize the research on reported type IV collagen subtypes and related diseases involving hearing loss to provide directions for future research.

关 键 词：IV型胶原蛋白 ALPORT综合征 听力损失 

分 类 号：R764[医药卫生—耳鼻咽喉科]