改良根治术联合放射性^(125)I粒子治疗乳腺癌对患者血清肿瘤标志物及生命质量的影响  

Effect of modified radical mastectomy combined with radioactive ^(125)I particles on serum tumor markers and quality of life in patients with breast cancer

作　　者：刘欢 LIU Huan(Department of Oncology,China Resources Liaojian Fuxin Mine General Hospital,Fuxin,Liaoning,123000,China)

机构地区：[1]华润辽健阜新矿总医院肿瘤外科,辽宁阜新123000

出　　处：《当代医学》2023年第33期54-57,共4页Contemporary Medicine

摘　　要：目的探讨改良根治术(MRM)联合放射性^(125)I粒子治疗乳腺癌对患者血清肿瘤标志物及生命质量的影响。方法选取2017年9月至2020年6月华润辽健阜新矿总医院收治的81例乳腺癌患者作为研究对象,根据治疗方法的不同分为MRM组(n=38)与联合组(n=43)。MRM组行MRM治疗,联合组在对照组基础上联合放射性^(125)I粒子治疗。比较两组临床疗效、癌症患者生命质量核心量表(EORTC QLQ-C30)评分及癌胚抗原(CEA)、细胞角质素片段抗原21-1(CYFRA21-1)、糖类抗原125(CA125)水平、预后情况。结果联合组客观缓解率(ORR)为83.72%,高于MRM组的63.16%,差异有统计学意义(P<0.05)。治疗后,两组总体功能、总体健康评分均高于治疗前,躯体症状评分均低于治疗前,且联合组总体功能、总体健康评分均高于MRM组,躯体症状评分低于MRM组,差异均有统计学意义(P<0.05)。治疗后,两组CEA、CYFRA21-1、CA125水平均低于治疗前,且联合组低于MRM组,差异有统计学意义(P<0.05)。联合组无病生存率高于MRM组,局部复发率、病死率均低于MRM组,差异有统计学意义(P<0.05);两组远期转移率比较差异无统计学意义。结论MRM联合放射性^(125)I粒子治疗乳腺癌疗效显著,可降低患者血清肿瘤标志物水平和复发率,有利于提高患者生命质量并改善远期预后,值得临床推广应用。Objective To investigate the effect of modified radical mastectomy(MRM)combined with radioactive ^(125)I particles on serum tumor markers and quality of life in patients with breast cancer.Methods 81 patients with breast cancer in China Resources Liaojian Fuxin Mine General Hospital from September 2017 to June 2020 were selected as the research subjects,and they were divided into the MRM group(n=38)and the combined group(n=43)according to different treatment methods.The MRM group was treated with MRM,and the combined group was treated with radioactive ^(125)I particles on the basis of the control group.The clinical efficacy,European organization for research and treatment of cancer,quality of life questionnaire-C30(EORTC QLQ-C30)score,levels of carcinoembryonic antigen(CEA),cytokeratin fragment antigen 21-1(CYFRA21-1)and carbohydrate antigen 125(CA125),prognosis were compared between the two groups.Results The objective response rate(ORR)in the combined group was 83.72%,which was higher than 63.16%in the MRM group,and the difference was statistically significant(P<0.05).After treatment,the overall function and overall health scores of the two groups were higher than those before treatment,and the scores of somatic symptoms were lower than those before treatment,and the overall function and overall health scores in the combined group were higher than those in the MRM group,and the scores of somatic symptoms were lower than those in the MRM group,and the differences were statistically significant(P<0.05).After treatment,the levels of CEA,CYFRA21-1 and CA125 of the two groups were lower than those before treatment,and the combined group was lower than that in the MRM group,and the differences were statistically significant(P<0.05).The disease-free survival rate in the combined group was higher than that in the MRM group,and the local recurrence rate and mortality rate were lower than that in the MRM group,and the differences were statistically significant(P<0.05).There was no significant difference in the long-term

关 键 词：乳腺癌 改良根治术 放射性125I粒子 肿瘤标志物 生命质量 

分 类 号：R737.9[医药卫生—肿瘤]