分析精神分裂症患者同型半胱氨酸水平与认知功能的相关性  

To analyze the correlation between homocysteine level and cognitive function in schizophrenic patients

作　　者：刘琼 谢小丽[1] 尹翼[1] 邓大禧 LIU Qiong;XIE Xiaoli;YIN Yi;DENG Daxi(Ji'an Third People's Hospital,Ji'an,Jiangxi,343000,China)

机构地区：[1]吉安市第三人民医院,江西吉安343000

出　　处：《当代医学》2023年第33期109-112,共4页Contemporary Medicine

摘　　要：目的分析精神分裂症(SCH)患者同型半胱氨酸水平与认知功能的相关性。方法选取2020年1月至2021年12月于吉安市第三人民医院住院的160例SCH患者作为观察组,另选取同期体检中心体检的160例健康人员作为对比组。两组均进行血清同型半胱氨酸(Hcy)水平检测,比较两组血清Hcy水平。将观察组Hcy水平正常患者纳入观察组19(Hcy≤15μmol/L为正常),Hcy水平升高患者纳入观察组2(Hcy>15μmol/L为增高),各80例,比较观察组1、观察组2蒙特利尔认知评估量表(MoCA)评分、阳性和阴性症状量表(PANSS)评分。采用Pearson相关性分析血清Hcy水平与MoCA评分、PANSS评分的相关性。结果观察组血清Hcy水平为(20.52±3.92)μmol/L,高于对比组的(12.16±1.04)μmol/L,差异有统计学意义(P<0.05)。观察组2执行功能、注意与集中、记忆、视结构机能、语言、抽象思维、计算、定向力评分及总分均低于观察组1,差异有统计学意义(P<0.05)。观察组2阴性症状、阳性症状、一般精神病理症状评分及总分均高于观察组1,差异有统计学意义(P<0.05)。血清Hcy水平与MoCA评分呈负相关性(r<0,P<0.05),血清Hcy水平与PANSS评分呈正相关性(r>0,P<0.05)。结论SCH患者血清Hcy水平与认知功能存在一定相关性,通过检测血清Hcy可评估患者认知功能受损程度。thinking,calculation,orientation and total score in the observation group 2 were lower than those in the observation group 1,and the differences were statistically significant(P<0.05).The negative symptoms,positive symptoms,general psychopathological symptoms scores and total scores in the observation group 2 were higher than those in the observation group 1,and the differences were statistically significant(P<0.05).There was negative correlation between serum Hcy and MoCA score(r<0,P<0.05),and positive correlation between serum Hcy and PANSS score(r>0,P<0.05).Conclusion Serum Hcy in SCH patients has a certain correlation with cognitive function,and the degree of cognitive function impairment can be assessed by detecting serum Hcy.

关 键 词：精神分裂症 同型半胱氨酸 精神症状 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]