自动分割海马亚区感兴趣区与3D-pCASL融合测量脑血流量一致性及可重复性  

Consistency and Repeatability of Cerebral Blood Flow by Automatic Segmentation of Region of Interest and 3D-pCASL Fusion in Hippocampal Subregions

作　　者：郭婷 闫梦楠 李金芹 王振华 李健 陈兵[3] GUO Ting;YAN Mengnan;LI Jinqin;WANG Zhenhua;LI Jian;CHEN Bing(Department of Radiology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;不详)

机构地区：[1]宁夏医科大学临床医学院,宁夏银川750004 [2]宁夏回族自治区人民医院放射科,宁夏银川750004 [3]宁夏医科大学总医院放射科,宁夏银川750004

出　　处：《中国医学影像学杂志》2024年第1期94-99,104,共7页Chinese Journal of Medical Imaging

基　　金：宁夏回族自治区重点研发计划(2020BEG03026)。

摘　　要：目的评价颞叶内侧癫痫伴海马硬化患者MRI影像研究中自动分割海马亚区感兴趣区(ROI)与动脉自旋标记(ASL)功能像融合测量脑血流量(CBF)的一致性及可重复性。资料与方法回顾性收集2021年1月—2022年10月宁夏医科大学总医院经MRI诊断或病理证实为海马硬化的52例颞叶内侧癫痫,患者均在3.0T MRI上采用轴位T1加权三维磁化强度预备梯度回波(3D-T1WI-MPRAGE)序列及三维伪连续式ASL序列进行扫描。对3D-T1WI-MPRAGE图像进行自动分割海马亚区,由2名医师进行海马亚区ROI与ASL功能图像融合并测量CBF值,分析测量者内、测量者间的一致性与可重复性。结果2名医师测得CBF值ICC均>0.750,平均为0.868±0.095,左、右侧海马各亚区ICC分别为:下托:0.818/0.801、海马角(CA)1:0.920/0.907、CA2~3:0.759/0.978、CA4:0.757/0.758、齿状回:0.990/0.991;同一名医师ROI勾画的ICC均>0.990,平均为0.994±0.002,左、右侧海马各亚区ICC分别为:下托:0.993/0.993、CA1:0.996/0.995、CA2~3:0.989/0.994、CA4:0.992/0.995、齿状回:0.993/0.996。BlandAltman图可直观展示散点分布和一致性,获取重复性系数。同一观察者对自动分割ROI与ASL功能像融合测量具有一定可重复性。结论基于自动分割海马亚区ROI与ASL功能像融合测量的CBF值具备较高的一致性及可重复性。Purpose To evaluate the consistency and repeatability of cerebral blood flow(CBF)values measured by automatic segmentation of region of interest(ROI)and arterial spin labeling(ASL)functional image fusion in hippocampal sclerosis patients with medial temporal lobe epilepsy.Materials and Methods From January 2021 to October 2022,a total of 52 patients with medial temporal lobe epilepsy confirmed by MRI or pathology in General Hospital of Ningxia Medical University were retrospectively collected.All subjects were scanned on 3.0T MRI to obtain axial T1 weighted three-dimensional magnetization reserve gradient echo(3D-T1W1-MPGAGE)sequence and three-dimensional pseudo continuous ASL sequence.The 3D-T1W1-MPGAGE imaging were automatically segmented.Two physicians used the freeview visualization interface of freeSurfer software to fuse the ROI and ASL functional images of the hippocampal subregions and to measure the CBF values.The intra-observer and inter-observer consistency and repeatability were evaluated and analyzed.The consistency analysis and repeatability evaluation were performed via intraclass correlation coefficient(ICC),Bland-Altman diagram and Wilcoxon rank sum test.Results The ICC of CBF values measured by two physicians were all>0.750,with an average of 0.868±0.095.The ICC of left and right hippocampal subregions were as follows:subiculum(SUB):0.818/0.801,cornu ammonis(CA)1:0.920/0.907,CA2-3:0.759/0.978,CA4:0.757/0.758 and dentate gyrus(DG):0.990/0.991;The ICC delineated by the same physician's ROI were all>0.990 with an average of 0.994±0.002.The ICC of left and right hippocampal subregions were as follows:SUB:0.993/0.993,CA1:0.996/0.995,CA2-3:0.989/0.994,CA4:0.992/0.995 and DG:0.993/0.996.The Bland-Altman diagram showed the scatter distribution and consistency,and the coefficient of repeatability was obtained.The same observer had certain repeatability for the fusion measurement of automatic segmentation ROI and ASL functional images.Conclusion The CBF values measured by fusing ROI and ASL functional i

关 键 词：癫痫 颞叶内侧 海马硬化 自动分割 海马亚区 磁共振成像 脑血流量 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]