铂基纳米制剂平台在医学多模态成像中的应用  

Platinum-Based Nanoplatforms in the Application of Medical Multimodal Imaging

作　　者：李贺莹 高京丕 郭鹏山 何卿豪 林蔓萍 顾硕 李景华[1,2] LI Heying;GAO Jingpi;GUO Pengshan;HE Qinghao;LIN Manping;GU Shuo;LI Jinghua(School of Medical Technology and Engineering,Henan University of Science and Technology,Luoyang 471003,China;College of Emergency and Trauma,Hainan Medical University,Haikou 571199,China)

机构地区：[1]河南科技大学医学技术与工程学院,河南洛阳471003 [2]海南医学院急诊创伤学院,海南海口571199

出　　处：《中国医学影像学杂志》2024年第1期105-108,112,共5页Chinese Journal of Medical Imaging

基　　金：国家自然科学基金(32260237,31800836)。

摘　　要：铂基纳米制剂平台由于铂的高原子序数存在,能够增强对X线的吸收,应用于CT成像。同时铂基纳米材料具有良好的近红外光吸收特性和光热转换效应,使其具有光热成像和光声成像能力。另外,通过减少横向和纵向弛豫时间,铂基纳米制剂平台可以介导MRI。本文对基于铂基纳米制剂平台的多模态成像系统引导癌症治疗诊疗平台开发和医学应用研究进行综述,分析利用铂基纳米制剂平台的多模态成像技术在癌症诊断和治疗中的应用前景,总结基于铂基纳米制剂平台在改善医学图像的对比度和提高癌症治疗效果方面的研究进展。Platinum-based nanoplatforms can enhance the absorption of X-ray due to the presence of high atomic number element of platinum and are applied to computed tomography imaging.Meanwhile,platinum-based nanomaterials have good near-infrared light absorption properties and photothermal conversion efficiency,which make them capable of photothermal imaging and photoacoustic imaging.In addition,by reducing transverse and longitudinal relaxation time,platinum-based nanoplatforms can mediate MRI imaging.In this paper,we report a multimodal imaging system based on platinum-based nanoplatforms for guiding the development of cancer treatment and diagnosis platform and medical application research,and also summarize the prospects of multimodal imaging technology in cancer diagnosis and treatment,report the research progress of platinum-based nanoplatforms in improving the contrast of medical images and enhancing cancer treatment.

关 键 词：铂化合物 多模态成像 体层摄影术 X线计算机 光热疗法 光声技术 综述 

分 类 号：R741[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]