^(18)F-PSMA PET/CT半定量参数与前列腺癌临床指标的相关性  

Correlation between 18F-PSMA PET/CT semi-quantitative parameters and clinical indicators of prostate cancer

作　　者：陈丹丹 楼云龙[1] CHEN Dandan;LOU Yunlong(Department of Nuclear Medicine,Meizhou People's Hospital,Guangdong,Meizhou 514013,China)

机构地区：[1]梅州市人民医院核医学科,梅州514013

出　　处：《现代泌尿生殖肿瘤杂志》2023年第6期335-340,共6页Journal of Contemporary Urologic and Reproductive Oncology

摘　　要：目的探讨前列腺癌18F-PSMA PET/CT半定量参数与前列腺癌各项临床指标的关系。方法回顾性分析梅州市人民医院核医学科2020年11月至2022年4月经病理证实为前列腺癌并行18F-PSMA PET/CT检查的60例患者,记录前列腺癌病灶最大标准摄取值(SUVmax)、平均标准摄取值(SUVavg),病灶PSMA体积(VPSMA)以及病灶PSMA总量(TLUPSMA)。比较不同Gleason评分、tPSA、世界卫生组织/国际泌尿病理协会(WHO/ISUP)分级及D’Amico风险分层组间SUVmax、SUVavg、VPSMA、TLUPSMA的差异有无统计学意义,并分析SUVmax、SUVavg、VPSMA、TLUPSMA与tPSA、fPSA、fPSA/tPSA、Gleason评分、WHO/ISUP分级和D’Amico风险分层的相关性。结果60例患者病灶摄取SUVmax、SUVavg、VPSMA、TLUPSMA的值分别为(36.1±32.8)、(9.1±7.0)、(57.0±48.6)及(670.3±1017.3)。SUVmax、SUVavg、VPSMA以及TLUPSMA与tPSA、fPSA、Gleason评分、WHO/ISUP分级及D’Amico风险分层均呈中度相关(均P<0.05,r值范围为0.45~0.59),而与fPSA/tPSA比值均不相关(均P>0.05),其中TLUPSMA与tPSA、fPSA、Gleason评分、WHO/ISUP分级和D’Amico风险分层相关性较好(r值分别为0.57、0.59、0.57、0.56和0.47,均P<0.001)。此外,SUVmax、SUVavg、VPSMA以及TLUPSMA在tPSA>20组及tPSA≤20组、Gleason评分>7组及Gleason评分≤7组、WHO/ISUP分级>2组及WHO/ISUP分级≤2组和D’Amico高风险及D’Amico低风险组的比较差异均有统计学意义(均P<0.05)。结论18F-PSMA PET/CT半定量参数与前列腺癌临床指标具有较好的相关性,其中TLUPSMA与各项指标的相关性最好,且在一定程度上可以反映临床相关指标,有助于临床制定个体化治疗方案。Objective To investigate the relationship between semiquantitative parameters of 18FPSMA PET/CT and clinicopathological characteristics of prostate cancer.Methods Sixty patients who were confirmed as prostate cancer and underwent preoperative 18F-PSMA PET/CT from November 2020 to April 2022 in our hospital were retrospectively analyzed,and the maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVavg),PSMA volume(VPSMA)and total lesion PSMA(TLUPSMA)of the prostate cancer lesions were recorded.The differences of semi-quantitative parameters among different clinicopathological characteristics were compared and the correlation between semi-quantitative parameters and the clinicopathological characteristics was analyzed.Results The SUVmax,SUVavg,VPSMA and TLUPSMA were(36.1±32.8),(9.1±7.0),(57.0±48.6)and(670.3±1017.3),respectively.SUVmax,SUVavg,VPSMA,and TLUPSMA were moderately associated with tPSA,fPSA,Gleason score,WHO/ISUP grade and D’Amico risk stratification(P<0.05),but not correlated with fPSA/tPSA ratio(P>0.05).There were significant differences in semi-quantitative parameters among different clinicopathological characteristics(all P<0.05).Conclusions A significant correlation is shown between 18F-PSMA PET/CT semiquantitative parameters and clinical parameters of prostate cancer,and TLUPSMA shows the best.It can reflect the clinical relevant indicators to a certain extent,which is helpful to formulate individualized treatment plan.

关 键 词：前列腺肿瘤 前列腺特异性抗原 正电子发射断层显像术 体层摄影术 X线计算机 半定量参数 

分 类 号：R737.25[医药卫生—肿瘤]