小牛血去蛋白提取物眼用凝胶在老年性硬核性白内障小切口摘除手术中的应用效果  

Application of deproteinized calf blood extract ophthalmic gel in small incision removal of senile hardcore cataract

作　　者：邢影 袁军[1] 赵笑雨 Xing Ying;Yuan Jun;Zhao Xiao-yu(Department of Ophthalmology,The Second People's Hospital of Zhengzhou,Zhengzhou 450015,China)

机构地区：[1]郑州市第二人民医院眼科,河南郑州450015

出　　处：《四川生理科学杂志》2024年第1期203-205,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:研究小牛血去蛋白提取物眼用凝胶在老年性硬核性白内障小切口摘除手术中的应用效果。方法:选取我院2021年6月至2022年12月诊治的老年性硬核性白内障患者152例(152眼)作为研究对象。随机将患者分为对照组和观察组,各76例。对照组采取小切口摘除术,观察组在对照组基础上加用小牛血去蛋白提取物眼用凝胶治疗。分析对比两组术前及术后1、8 w的视力、前房炎性反应、角膜内皮细胞相关参数,其中视力采用标准视力量表测定,角膜内皮细胞相关参数采用SP-1P非接触型的角膜内皮细胞仪测量。结果:观察组术后1 w、8 w的矫正视力均较对照组显著提高(P<0.05);术后1 w前房炎性反应较对照组减轻(P<0.05)。两组术后1 w中央角膜厚度高于术前,而六边形细胞的比例、角膜内皮细胞的密度均显著低于术前;术后8 w中央角膜厚度显著低于术后1 w,六边形细胞的比例、角膜内皮细胞的密度均显著高于术后1 w;且观察组患者的术后1 w中央角膜厚度显著低于对照组,而六边形细胞的比例、角膜内皮细胞的密度显著高于对照组(P<0.05)。结论:小牛血去蛋白提取物眼用凝胶在老年性硬核性白内障小切口摘除手术中,能改善角膜内皮细胞相关参数。Objective:To study the effect of deproteinized calf blood extract eye gel in small incision removal of senile hardcore cataract.Methods:152 patients(152 eyes)with senile sclerotic cataract treated in our hospital from June 2021 to December 2022 were selected as the study objects.The patients were randomly divided into control group and observation group,76 cases each.The control group was operated with small incision,and the observation group was treated with eye gel of deproteinized calf blood on the basis of control group.The visual acuity,anterior chamber inflammatory response and corneal endothelial cell related parameters of the two groups were analyzed and compared before and 1 and 8 weeks after surgery.The visual acuity was measured by standard visual acuity scale,and the corneal endothelial cell related parameters were measured by SP-1P non-contact corneal endothelial cell meter.Results:The corrected visual acuity of the observation group at 1 week and 8 weeks after operation was significantly higher than that of the control group(P<0.05).The atrial inflammatory response was less than that of control group 1 week after surgery(P<0.05).The central corneal thickness was higher than that before surgery,but the proportion of hexagonal cells and the density of corneal endothelial cells were significantly lower than before surgery.The central corneal thickness at 8 weeks after surgery was significantly lower than that at 1 week after surgery,the proportion of hexagonal cells and the density of corneal endothelial cells were significantly higher than that at 1 week after surgery.The central corneal thickness of observation group was significantly lower than that of control group one week after surgery,while the proportion of hexagonal cells and the density of corneal endothelial cells were significantly higher than that of control group(P<0.05).Conclusion:Calf blood deproteinized eye gel can improve corneal endothelial cell parameters in small incision for senile scleral cataract extraction.

关 键 词：硬核性白内障 小切口摘除术 小牛血清去蛋白眼用凝胶 前房炎症反应 

分 类 号：R779.66[医药卫生—眼科]