基于双联抗方案的经导管选择性脑动脉内介入溶栓术治疗急性缺血性脑卒中的效果及对脑氧摄取率、神经功能的影响  

Effect of transcatheter selective cerebral artery interventional thrombolysis based on dual antiplatelet regimen in the treatment of acute ischemic stroke and its influences on cerebral oxygen uptake rate and neurological function

作　　者：巨岩 贺晓磊 贾晓涛[3] JU Yan;HE Xiaolei;JIA Xiaotao(Yangling Demonstration Zone Hospital,Xianyang 712100;Yangxian People's Hospital,Hanzhong 723300;Xi'an Central Hospital,Xi'an 710003,China)

机构地区：[1]杨凌示范区医院,陕西咸阳712100 [2]洋县人民医院,陕西汉中723300 [3]西安市中心医院,陕西西安710003

出　　处：《临床医学研究与实践》2024年第4期70-73,共4页Clinical Research and Practice

基　　金：陕西省重点研发计划项目(No.2018SF-036)。

摘　　要：目的分析基于双联抗方案的经导管选择性脑动脉内介入溶栓术治疗急性缺血性脑卒中的效果。方法选取2020年1月至12月收治的100例急性缺血性脑卒中患者为研究对象,以随机数字表法将其分为常规组(50例,常规抗凝+经导管选择性脑动脉内介入溶栓术治疗)和观察组(50例,基于双联抗方案的经导管选择性脑动脉内介入溶栓术治疗)。比较两组的治疗效果。结果观察组的治疗总有效率为98.00%,高于常规组的84.00%(P<0.05)。治疗第1天、第7天、1个月后,观察组的脑氧摄取率低于常规组(P<0.05)。治疗1个月后,观察组的美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)评分低于常规组(P<0.05)。治疗1个月后,观察组的最大血流速度(Vmax)、最小血流速度(Vmin)及平均血流量(Qmean)均高于常规组,脑血管外周阻力(RV)低于常规组(P<0.05)。结论基于双联抗方案的经导管选择性脑动脉内介入溶栓术治疗急性缺血性脑卒中可取得理想的治疗效果。Objective To analyze the effect of transcatheter selective cerebral artery interventional thrombolysis based on dual antiplatelet regimen in the treatment of acute ischemic stroke.Methods A total of 100 patients with acute ischemic stroke admitted from January to December 2020 were selected as the research objects,and the patients were divided into conventional group(50 cases,routine anticoagulation+transcatheter selective cerebral artery interventional thrombolysis)and observation group(50 cases,transcatheter selective cerebral artery interventional thrombolysis based on dual antiplatelet regimen)by random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 98.00%,which was higher than 84.00%in the conventional group(P<0.05).On the 1st day,7th day and 1 month after treatment,the cerebral oxygen uptake rate of the observation group was lower than that of the conventional group(P<0.05).After 1 month of treatment,the National Institutes of Health Stroke Scale(NIHSS)and modified Rankin Scale(mRS)scores of the observation group were lower than those of the conventional group(P<0.05).After 1 month of treatment,the maximum blood flow velocity(Vmax),minimum flow velocity(Vmin)and mean blood flow(Qmean)in the observation group were higher than those in the conventional group,and the vascular resistance(RV)was lower than that in the conventional group(P<0.05).Conclusion Transcatheter selective cerebral artery interventional thrombolysis based on dual antiplatelet regimen in the treatment of acute ischemic stroke can achieve ideal therapeutic effect.

关 键 词：急性缺血性脑卒中 双联抗方案 经导管选择性脑动脉内介入溶栓术 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]