“智三针”联合高压氧对脑梗死后血管性认知障碍患者认知功能及日常生活活动能力的影响  

Effect of"Zhisanzhen"combined with hyperbaric oxygen on cognitive function and activities of daily living in patients with vascular cognitive impairment after cerebral infarction

作　　者：罗增媛 李俊 胡结林 李娇[3] 熊建忠[1] LUO Zengyuan;LI Jun;HU Jielin;LI Jiao;XIONG Jianzhong(Department of Rehabilitation Medicine,Pingxiang People's Hospital,Jiangxi Province,Pingxiang337000,China;Department of Neurology,Pingxiang People's Hospital,Jiangxi Province,Pingxiang337000,China;Department of Traditional Chinese Medicine,Pingxiang People's Hospital,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡市人民医院康复医学科,江西萍乡337000 [2]江西省萍乡市人民医院神经内科,江西萍乡337000 [3]江西省萍乡市人民医院中医科,江西萍乡337000

出　　处：《中国当代医药》2024年第3期92-95,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2022B144)。

摘　　要：目的探讨“智三针”联合高压氧治疗脑梗死后血管性认知障碍(VCI)的临床效果。方法选取2021年5月至2023年5月萍乡市人民医院收治的90例脑梗死后VCI患者作为研究对象,按随机数字表法将其分为三组,每组各30例。三组均予以常规脑梗死治疗,对照1组予以“智三针”治疗,对照2组予以高压氧治疗,观察组予以“智三针”联合高压氧治疗,持续3个疗程。比较三组的临床疗效、认知功能、日常生活活动能力。结果观察组患者的总有效率高于对照1组、对照2组,差异有统计学意义(P<0.017);观察组患者治疗后的简易精神量表(MMSE)评分、蒙特利尔认知功能量表(MoCA)评分[(28.41±1.23)、(28.74±1.32)分]高于对照2组[(24.36±1.58)、(25.02±1.29)分]和对照1组[(24.42±1.63)、(25.08±1.31)分],差异有统计学意义(P<0.05)。观察组患者治疗后的Barthel指数(BI)评分[(60.58±5.36)分]高于对照2组[(50.41±5.22)分]和对照1组[(50.57±5.25)分],差异有统计学意义(P<0.05)。结论“智三针”联合高压氧可提高脑梗死后VCI治疗效果,加快患者认知功能恢复,减轻氧化应激损伤及血管内皮障碍,改善日常生活活动能力。Objective To explore the clinical effect of"Zhisanzhen"combined with hyperbaric oxygen on vascular cognitive impairment(VCI)after cerebral infarction.Methods Ninety patients with VCI after cerebral infarction admitted to Pingxiang People's Hospital from May 2021 to May 2023 were selected as the study objects and divided into three groups according to random number table method,with 30 cases in each group.All the three groups were given conventional cerebral infarction treatment,control group 1 was given"Zhisanzhen"treatment,control group 2 was given hyperbaric oxygen treatment,observation group was given"Zhisanzhen"combined with hyperbaric oxygen treatment,lasting 3 courses.The clinical efficacy,cognitive function and daily living ability of the three groups were compared.Results The total effective rate of observation group was higher than control group 1 and control group 2,and the difference was statistically significant(P<0.017).After treatment,the scores of mini mental state examination(MMSE)and Montreal cognitive assessment(MoCA)in observation group([28.41±1.23],[28.74±1.32]points)were higher than those in control group 2([24.36±1.58],[25.02±1.29]points)and control group 1([24.42±1.63],[25.08±1.31]points),the differences were statistically significant(P<0.05).The Barthel index(BI)score of observation group([60.58±5.36]points)was higher than that of control group 2([50.41±5.22]points)and control group 1([50.57±5.25]points)after treatment,and the difference was statistically significant(P<0.05).Conclusion"Zhisanzhen"combined with hyperbaric oxygen can improve the therapeutic effect of VCI after cerebral infarction,accelerate the recovery of cognitive function,alleviate oxidative stress injury and vascular endothelial dysfunction,and improve the ability of daily living.

关 键 词：脑梗死 血管性认知障碍 “智三针” 高压氧 认知功能 日常生活活动能力 

分 类 号：R743.33[医药卫生—神经病学与精神病学]