β-榄香烯对肺腺癌术后化疗患者炎症反应和免疫因子γ干扰素的影响  

Effect of β-elemene on inflammatory response and interferon-γof patients with lung adenocarcinoma after chemotherapy

作　　者：王小卫 濮忠建 包军军 贾燕华 WANG Xiaowei;PU Zhongjian;BAO Junjun;JIA Yanhua(Department of Surgery,Hai’an Hospital of Traditional Chinese Medicine,Jiangsu Province,Hai’an 226600,China;Department of Oncology,Hai’an Hospital of Traditional Chinese Medicine,Jiangsu Province,Hai’an 226600,China;Department of Thoracic Surgery,Hai’an Hospital of Traditional Chinese Medicine,Jiangsu Province,Hai’an 226600,China;Department of Internal Medicine,Hai’an Hospital of Traditional Chinese Medicine,Jiangsu Province,Hai’an 226600,China)

机构地区：[1]江苏省海安市中医院外科,江苏海安226600 [2]江苏省海安市中医院肿瘤科,江苏海安226600 [3]江苏省海安市中医院胸外科,江苏海安226600 [4]江苏省海安市中医院内科,江苏海安226600

出　　处：《中国医药导报》2023年第35期128-131,共4页China Medical Herald

基　　金：江苏省南通市科技计划项目(MSZ2022070)。

摘　　要：目的探讨β-榄香烯对肺腺癌术后化疗患者炎症反应和免疫因子γ干扰素(INF-γ)的影响。方法选择2018年2月至2021年1月江苏省海安市中医院收治的92例肺腺癌术后患者,根据随机数字表法将其分为研究组与对照组,各46例。对照组接受术后化疗(卡铂联合培美曲塞),研究组在对照组的基础上接受β-榄香烯治疗。比较两组临床疗效,血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)、糖类抗原199(CA199)、IFN-γ,不良反应。结果在研究过程中对照组脱落3例。研究组临床疗效优于对照组(P<0.05)。治疗后,两组血清TNF-α、IL-2、CA199水平低于治疗前,且研究组低于对照组(P<0.05)。治疗后,两组血清INF-γ水平均高于治疗前,且研究组高于对照组(P<0.05)。两组静脉炎、肝肾功能损害、消化道反应等级分布比较,差异无统计学意义(P>0.05)。结论β-榄香烯用于治疗肺腺癌术后化疗患者效果确切,可减轻炎症反应,调节肿瘤标志物水平,改善免疫功能,安全可靠。Objective To investigate the effect ofβ-elemene on inflammatory response and immune factor interferon-γ(INF-γ)in patients with lung adenocarcinoma after chemotherapy.Methods Ninety-two patients with lung adenocarcinoma treated in Hai’an Hospital of Traditional Chinese Medicine from February 2018 to January 2021 were selected and they were divided into study group and control group according to random number table method,with 46 cases in each group.The control group received postoperative chemotherapy(Carboplatin combined with Pemetrexed),and the study group receivedβ-elemene therapy on the basis of the control group.The clinical efficacy,serum interleukin-2(IL-2),tumor necrosis factor-α(TNF-α),carbohydrate antigen 199(CA199),IFN-γ,and adverse reactions of the two groups were compared.Results There were three cases fell of in the control group during the study.The clinical effect of the study group was better than control group(P<0.05).After treatment,the serum levels of TNF-α,IL-2,and CA199 in two groups were lower than before treatment(P<0.05),and those of the study group were lower than control group(P<0.05).After treatment,the INF-γlevel in two groups was higher than before treatment(P<0.05),and the study group was higher than control group(P<0.05).There were no differences in the grade distribution of phlebitis,liver and kidney damage,and digestive tract reaction between the two groups(P>0.05).Conclusionβ-elemene is effective in the treatment of patients with lung adenocarcinoma after chemotherapy.It can reduce inflammatory response,regulate the level of tumor markers,improve immune function,and is safe and reliable.

关 键 词：Β-榄香烯 肺腺癌 化疗 炎症反应 Γ干扰素 安全性 

分 类 号：R734.2[医药卫生—肿瘤]