阻塞性低通气睡眠呼吸暂停综合征中年患者认知功能特点及相关影响因素分析  

Analysis of cognitive function characteristics and related influencing factors in middle-aged patients with obstructive hypopnea sleep apnea syndrome

作　　者：王红雨[1] 高倩 朱麒霖 王美兰[2] WANG Hongyu;GAO Qian;ZHU Qilin;WANG Meilan(Department of Pneumology,the Third People’s Hospital of Nantong City Nantong Third Hospital Affiliated to Nantong University,Jiangsu Province,Nantong 226006,China;Department of Nursing,the Third People’s Hospital of Nantong City Nantong Third Hospital Affiliated to Nantong University,Jiangsu Province,Nantong 226006,China)

机构地区：[1]江苏省南通市第三人民医院南通大学附属南通第三医院呼吸科,江苏南通226006 [2]江苏省南通市第三人民医院南通大学附属南通第三医院护理部,江苏南通226006

出　　处：《中国医药导报》2023年第36期67-70,共4页China Medical Herald

基　　金：江苏省自然科学基金青年科学基金资助项目(BK20190129)。

摘　　要：目的 分析阻塞性低通气睡眠呼吸暂停综合征(OSAHS)中年患者认知功能特点及相关影响因素。方法 将江苏省南通市第三人民医院2022年1月至11月收治的OSAHS中年患者98例纳入观察组,同期将98例中年健康体检者纳入对照组。收集两组基线资料,并进行蒙特利尔认知评估、多导睡眠监测,分析OSAHS患者认知功能特点及相关影响因素。结果 观察组呼吸暂停次数高于对照组,最长呼吸暂停时间及平均呼吸暂停时间长于对照组,最低动脉血氧饱和度(SaO_(2))及平均水平SaO_(2)低于对照组,差异有统计学意义(P<0.05)。观察组蒙特利尔认知评估量表注意力、延迟记忆、视空间与执行维度评分低于对照组(P<0.05)。logistic分析结果显示,患者SaO_(2)水平为OSAHS患者认知功能损伤的独立危险因素(OR>1,P<0.05)。结论 OSAHS可导致患者认知功能损伤,并且集中表现为注意力、延迟记忆及视空间与执行功能障碍,SaO_(2)水平为OSAHS患者发生认知功能损伤的独立危险因素,临床可采取针对性干预措施以降低患者认知功能损伤风险。Objective To analyze the cognitive function characteristics and related influencing factors of middle-aged patients with obstructive hypopnea sleep apnea syndrome(OSAHS).Methods A total of 98 middle-aged patients with OSAHS admitted to the Third People’s Hospital of Nantong City from January to November 2022 were included in the observation group,and 98 middle-aged healthy subjects were included in the control group during the same period.Baseline data of the two groups were collected,and Montreal cognitive assessment and polysomnography monitoring were performed to analyze the cognitive function characteristics and related influencing factors of OSAHS patients.Results The frequency of apnea in the observation group was higher than that in the control group,the longest apnea time and the average apnea time were longer than that in the control group,and the minimum oxygen saturation in arterial blood(SaO_(2))and the average level of SaO_(2) were lower than that in the control group,and the differences were statistically significant(P<0.05).The scores of attention,delayed memory,visual space,and executive dimension of the Montreal cognitive assessment scale in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Logistic analysis showed that SaO_(2) level was an independent risk factor for cognitive impairment in OSAHS patients(OR>1,P<0.05).Conclusion OSAHS can lead to cognitive impairment in patients,and the concentrated manifestations are attention,delayed memory,visuospatial and executive dysfunction.SaO_(2) level is an independent risk factor for cognitive impairment in patients with OSAHS.Targeted intervention measures can be taken to reduce the risk of cognitive impairment in patients.

关 键 词：阻塞性低通气睡眠呼吸暂停综合征 认知功能 动脉血氧饱和度 影响因素 

分 类 号：R742[医药卫生—神经病学与精神病学]