电生理视觉诱发电位检测联合血清脂肪特异性丝氨酸蛋白酶抑制剂表达在糖尿病视神经病变中的诊断价值  

Diagnostic value of electrophysiological visual evoked potential detection combined with serum visceral adipose-specific serine protease inhibitor expression in diabetic optic neuropathy

作　　者：张素雅 王菁 ZHANG Suya;WANG Jing(Department of Ophthalmology,Sir Run Run Hospital Nanjing Medical University,Jiangsu Province,Nanjing 211100,China)

机构地区：[1]南京医科大学附属逸夫医院眼科,江苏南京211100

出　　处：《中国医药导报》2023年第36期104-107,共4页China Medical Herald

基　　金：江苏省自然科学基金项目(BK20200163)。

摘　　要：目的 研究电生理视觉诱发电位(VEP)检测联合血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)表达在糖尿病视神经病变(DON)中的诊断价值。方法 回顾性分析2020年1月至2022年7月南京医科大学附属逸夫医院收治的259例(518眼)2型糖尿病患者的临床资料,根据有无DON分为非DON组(238例,476眼)与DON组(21例,42眼)。分析糖尿病患者发生DON的影响因素,分析电生理VEP检测、血清Vaspin表达对DON的预测价值。结果 DON组糖尿病病程、P100潜时长于非DON组,血清Vaspin水平高于非DON组,P100波幅低于非DON组(P<0.05)。糖尿病病程(OR=4.289)、P100潜时(OR=2.838)、P100波幅(OR=0.328)、血清Vaspin(OR=3.466)为糖尿病患者发生DON的影响因素(P<0.05)。P100潜时、P100波幅联合血清Vaspin水平诊断DON的曲线下面积高于各项单独预测(P<0.05)。结论 电生理VEP检测(P100潜时、P100波幅)、血清Vaspin水平在诊断DON中具有重要价值,且三者联合具有更高的诊断价值。Objective To investigate the diagnostic value of electrophysiological visual evoked potential(VEP)detection combined with serum visceral adipose-specific serine protease inhibitor(Vaspin)expression in diabetic optic neuropathy(DON).Methods Clinical data of 259 patients(518 eyes)with type 2 diabetes mellitus admitted to Sir Run Run Hospital Nanjing Medical University from January 2020 to July 2022 were retrospectively analyzed,and they were divided into non-DON group(238 cases,476 eyes)and DON group(21 cases,42 eyes)according to whether they had DON or not.The factors affecting the occurrence of DON in diabetic mellitus patients were analyzed,and the diagnostic value of electrophysiological VEP detection and serum Vaspin expression for DON was analyzed.Results Duration of diabetes mellitus,P100 latent time in DON group were longer than those in non-DON group,serum Vaspin level was higher than that in non-DON group,and P100 amplitude was lower than that in non-DON group(P<0.05).Duration of diabetes mellitus(OR=4.289),P100 latent time(OR=2.838),P100 amplitude(OR=0.328),and serum Vaspin(OR=3.466)were influencing factors for the occurrence of DON in diabetic mellitus patients(P<0.05).The area under the curve of P100 latent time and P100 amplitude combined with serum Vaspin level in diagnosis of DON was higher than that in each single prediction(P<0.05).Conclusion Electrophysiological VEP detection(P100 latent time,P100 amplitude)and serum Vaspin level have important value in the diagnosis of DON,and the combination of the three has higher diagnostic value.

关 键 词：电生理视觉诱发电位 脂肪特异性丝氨酸蛋白酶抑制剂 糖尿病视神经病变 诊断价值 

分 类 号：R774.6[医药卫生—眼科]