碳离子治疗结直肠癌的基础与临床研究进展  

Basic and clinical research progress in carbon ion therapy for colorectal cancer

作　　者：任祥清 黄田 王玉平 胡泽楠[1,2] 周永宁[1,2] Ren Xiangqing;Huang Tian;Wang Yuping;Hu Zenan;Zhou Yongning(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院消化内科,兰州730000

出　　处：《中华放射肿瘤学杂志》2024年第1期67-71,共5页Chinese Journal of Radiation Oncology

基　　金：甘肃省自然科学基金(22JR5RA902);甘肃省教育厅科技创新基金项目(2022B-001)。

摘　　要：结直肠癌是临床常见的恶性肿瘤,放射治疗作为结直肠癌的主要治疗方法,对肿瘤进展有较好的抑制作用。近年来,碳离子因其良好的物理学及生物学优势,在对结直肠癌局部复发或者远处转移的治疗中,表现出比传统放疗更好的临床效果。本文主要回顾了近年来碳离子治疗结直肠癌复发的相关基础与临床研究,以期为预防和减少结直肠癌患者放疗后不良反应及延长患者生存期提供理论依据。Colorectal cancer is a common clinical malignant tumor.As the main therapeutic method of colorectal cancer,radiotherapy has a good inhibitory effect on tumor progression.In recent years,because of its good physical and biological advantages,carbon ion has shown better clinical efficacy than traditional radiotherapy in the treatment of local recurrence or distant metastasis of colorectal cancer.In this article,basic and clinical studies related to the efficacy of carbon ion therapy for the recurrence of colorectal cancer in recent years were reviewed,aiming to provide theoretical basis for preventing and reducing adverse reactions after radiotherapy and prolonging the survival of colorectal cancer patients.

关 键 词：重离子放射疗法 碳离子 结直肠肿瘤 肿瘤复发 自噬 放疗增敏 P53基因 肠道菌群 

分 类 号：R735.3[医药卫生—肿瘤]