Polysaccharide based supramolecular injectable hydrogels for in situ treatment of bladder cancer  

作　　者：Chang Zhang Jie Niu Jianqiu Li Hui Zhang Qilin Yu Yong Chen Yu Liu 

机构地区：[1]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China [2]College of Life Sciences,Key Laboratory of Molecular Microbiology and Technology,Nankai University,Tianjin 300071,China

出　　处：《Chinese Chemical Letters》2024年第1期259-263,共5页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China(Nos.22131008 and 21971127);the Haihe Laboratory of Sustainable Chemical Transformations for financial support.

摘　　要：Implantable system maximizes drug concentration and continuously releases drugs near the tumor,which is an effective tool to solve the difficult retention of chemotherapy drugs in bladder cancer.In this work,a novel polysaccharide supramolecular injectable hydrogel(CCA hydrogels for short)is rapidly constructed by simply mixing cationic chitosan,anionic sulfobutyl etherβ-cyclodextrin(SBE-β-CD)and a trace amount of silver ions.The injected hydrogel reconstituted and regained its shape in less than 1 h,and it can still maintain the elasticity suitable for the human body.By packaging the drug directly,the gel achieves a high concentration of doxorubicin,an anticancer drug.Using MB49-luc cells as the model of bladder tumor for anti-tumor in vivo,the CCA-DOX gel has obvious inhibitory effect on bladder tumor,and its inhibitory effect is much greater than that of free DOX.Therefore,this self-healing injectable hydrogel has great potential for in situ treatment of bladder cancer.

关 键 词：Sulfobutylether-β-cyclodextrin Supramolecular chemistry CHITOSAN Injectable hydrogel Bladder cancer Local chemotherapy 

分 类 号：R737.14[医药卫生—肿瘤] TQ427.26[医药卫生—临床医学]