J-aggregation of photosensitizers leads to an ultrahigh drug-loading system for targeted delivery  

作　　者：Yun Qu Wenjuan Jin Yichen Wan Zhichao Pei Yuxin Pei 

机构地区：[1]College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China

出　　处：《Chinese Chemical Letters》2024年第1期271-274,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22171230 and 21877088);the Project of Science and Technology of Social Development in Shaanxi Province(No.2021SF-120)。

摘　　要：Drug loading capacity is very important in the construction of targeted drug delivery systems(TDDSs)for the improvement of drug delivery efficiency.However,the drug-loading capacity of most nanomaterials is non-idealistic,and developing the high drug-loading TDDSs is still a critical challenge.In this work,an ultrahigh loading system(denoted as HMPB_(2))was prepared via J-aggregation of an aza-boron dipyrromethene derivative(Bod)by using hollow MnO_(2)modified with glucosamine pillar[5]arene as a carrier,which was demonstrated to have typical J-aggregate absorption of Bod,specific cancer cells targeting ability,negligible dark cytotoxicity,and potent phototoxicity.This work provides a successful example to construct an ultrahigh drug-loading system via J-aggregation for targeted delivery.

关 键 词：J-AGGREGATE Ultrahigh drug-loading Aza-BODIPY Hollow MnO_(2) PHOTOTHERAPY Pillar[n]arene 

分 类 号：TQ460.1[化学工程—制药化工]