代谢工程产2′-岩藻糖基乳糖的研究  

Research progress on the production of 2′-fucosyllactose in metabolic engineering

作　　者：涂班策 黄广文 黄明珠 刘斌 陈雪岚[1,2] TU Bance;HUANG Guangwen;HUANG Mingzhu;LIU Bin;CHEN Xuelan(College of Life Science and National R&D Center for Freshwater Fish Processing,Jiangxi Normal University,Nanchang 330027,China;Health College,Jiangxi Normal University,Nanchang 330027,China)

机构地区：[1]江西师范大学生命科学学院,国家淡水鱼加工技术研发专业中心,江西南昌330027 [2]江西师范大学健康学院,江西南昌330027

出　　处：《食品与发酵工业》2024年第2期329-334,共6页Food and Fermentation Industries

基　　金：国家自然科学基金(32260014,31960014);江西省自然科学基金(20224BAB215004,20224BAB215005)。

摘　　要：人乳低聚糖(human milk oligosaccharide,HMO)是存在人母乳中的重要组成成分,与婴儿的健康和发育密切相关。2-岩藻糖基乳糖(2′-fucosyllactose,2′-FL)是HMO中含量最丰富的成分,具有显著的营养价值和药用价值,如促进婴儿大脑发育、提高婴儿免疫力等。现如今合成2′-FL的方法有直接提取、化学合成、酶促合成以及微生物发酵法,但前3种方法存在诸多限制及不足,微生物发酵法成为最有潜力的方法。该文对利用微生物进行改造从而提高2′-FL产量的研究进行了综述,以期为相关研究者提供参考。Human milk oligosaccharides(HMOs)are important components presenting in human breast milk and closely related to the health and development of infants.2-Fucosyllactose(2′-FL),as the most abundant component in HMO,has significant nutritional and medicinal value,such as promoting infant brain development and improving infant immunity.At present,the synthesis methods of 2′-FL include direct extraction,chemical synthesis,enzymatic synthesis,and microbial fermentation.However,there are many limitations and deficiencies in direct extraction,chemical synthesis and enzymatic synthesis,and microbial fermentation might be the most potential method.In the paper,the studies on the improvement of 2′-FL yield by microbial modification are reviewed,in order to provide reference for the relevant researchers.

关 键 词：人乳低聚糖 2′-岩藻糖基乳糖 微生物发酵 代谢工程 futC 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]