组蛋白乳酸化修饰在非肿瘤疾病中的作用  

Roles of histone lactylation in non-tumor diseases

作　　者：章婷婷[1] 赵调红 李雯 杨蕊 代鹏钰 杨楠 马昕芸 刘会玲[2] ZHANG Tingting;ZHAO Tiaohong;LI Wen;YANG Rui;DAI Pengyu;YANG Nan;MA Xinyun;LIU Huiling(The First Clinical Medical College,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Gynecology,Gansu Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省人民医院妇科,兰州730000

出　　处：《生命的化学》2023年第12期1840-1846,共7页Chemistry of Life

基　　金：国家自然科学基金项目(82260557);甘肃省自然科学基金项目(21JR1RA018);新锐肿瘤支持治疗课题研究公益项目(cphcf-2022-012)。

摘　　要：组蛋白乳酸化修饰是一种由乳酸介导的新型蛋白质翻译后修饰,参与炎症、纤维化和促血管生成等多种病理生理过程,与神经系统、呼吸系统和生殖系统等疾病密切相关,亦是潜在的药物新靶标。本文简要介绍了组蛋白乳酸化修饰的生物学功能及其在非肿瘤性疾病中的作用,为相关疾病的治疗和干预提供新思路,亦有助于了解组蛋白乳酸化修饰的功能和机制。Histone lactylation is a novel post-translational modification mediated by lactic acid,which plays a role in various pathophysiological processes,including inflammation,fibrosis and pro-angiogenesis.It is closely associated with neurological,respiratory,and reproductive disorders and is potential drug targets.This paper briefly introduces the biological functions of histone lactylation and its roles in non-tumor diseases.These findings may offer novel ideas for the treatment and intervention of related diseases and provide insights into the functions and mechanisms of histone lactylation.

关 键 词：组蛋白翻译后修饰 组蛋白乳酸化 生物学功能 

分 类 号：R363[医药卫生—病理学]