Type 2 immunity in the brain and brain borders  

作　　者：Tornike Mamuladze Jonathan Kipnis 

机构地区：[1]Center for Brain Immunology and Glia(BIG),Washington University in St.Louis,St.Louis,MO,63110,USA [2]Department of Pathology and Immunology,School of Medicine,Washington University in St.Louis,St.Louis,MO,63110,USA [3]Immunology Graduate Program,School of Medicine,Washington University in St.Louis,St.Louis,MO,63110,USA

出　　处：《Cellular & Molecular Immunology》2023年第11期1290-1299,共10页中国免疫学杂志（英文版）

摘　　要：Recent research in neuroimmunology has revolutionized our understanding of the intricate interactions between the immune system and the central nervous system(CNS).The CNS,an“immune-privileged organ”,is now known to be intimately connected to the immune system through different cell types and cytokines.While type 2 immune responses have traditionally been associated with allergy and parasitic infections,emerging evidence suggests that these responses also play a crucial role in CNS homeostasis and disease pathogenesis.Type 2 immunity encompasses a delicate interplay among stroma,Th2 cells,innate lymphoid type 2 cells(ILC2s),mast cells,basophils,and the cytokines interleukin(IL)-4,IL-5,IL-13,IL-25,TSLP and IL-33.In this review,we discuss the beneficial and detrimental roles of type 2 immune cells and cytokines in CNS injury and homeostasis,cognition,and diseases such as tumors,Alzheimer’s disease and multiple sclerosis.

关 键 词：Type 2 immunity Meningeal immunity NEUROIMMUNOLOGY 

分 类 号：R392[医药卫生—免疫学]