Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids  

作　　者：Jian Zhou Min Wu Gen Yang 

机构地区：[1]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000 Zhejiang,China [2]School of Physics,Peking University,100871 Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第12期5572-5574,共3页信号转导与靶向治疗（英文）

基　　金：support from research grants provided by the National Natural Science Foundation of China(12375334);the National Key Research and Development Program of China(Grant No.2022YFD1201600);the Key Program of Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2021015).

摘　　要：In a recent publication in Nature,1 Mamedov and colleagues identified pathways that modulateγδT cell killing and BTN3A cellular expression through integrating genome-wide CRISPR screens and tumor organoid culture,deepening our comprehension ofγδT cell stress surveillance and proposing novel pathways to boostγδT cell’s anticancer functions(Fig.1).

关 键 词：integrating DEEPENING culture 

分 类 号：R730.5[医药卫生—肿瘤]