残余胆固醇水平与老年急性脑梗死患者椎基底动脉延长扩张症的相关性研究  

Correlation between residual cholesterol level and vertebrobasilar artery dilatation in elderly patients with acute cerebral infarction

作　　者：梅雨晴[1] 郭言伟 张文婷 张敏[1] 杨桂美[2] Mei Yuqing;Guo Yanwei;Zhang Wenting;Zhang Min;Yang Guimei(Department of Neurology Changzhou Second People’s Hospital,Nanjing Medical University Changzhou 213000,Jiangsu Province China)

机构地区：[1]南京医科大学附属常州市第二人民医院神经内科、南京医科大学常州医学中心,213000 [2]南京医科大学附属常州市第二人民医院急诊科,213000 [3]合肥市第二人民医院神经内科

出　　处：《中华老年心脑血管病杂志》2023年第12期1324-1327,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：南京医科大学常州医学中心临床项目(CMCC202207);常州市卫生健康人才国内外研修项目(GN2023011)。

摘　　要：目的探讨残余胆固醇(RC)水平与老年急性脑梗死患者椎基底动脉延长扩张症(VBD)的相关性。方法连续回顾性纳入2020年1月至2021年7月南京医科大学附属常州市第二人民医院神经内科收治的急性脑梗死患者325例,所有患者均完成头颅MRI、头颈部CT血管成像(CTA)检查及血浆TC、TG、LDL-C、HDL-C等生化指标测定。入组患者根据影像学诊断标准分为VBD组52例和非VBD组273例,比较2组临床资料的差异,分析RC水平与老年急性脑梗死患者VBD的关系。结果VBD组年龄、男性、高血压、吸烟、TG、RC水平高于非VBD组,差异有统计学意义(P<0.05,P<0.01)。采用多因素logistic回归分析,校正年龄、男性、高血压等混杂因素后发现,年龄(OR=1.126,95%CI:1.065~1.191,P=0.000)、男性(OR=4.163,95%CI:11.173~10.120,P=0.002)、RC水平(OR=1.270,95%CI:1.151~1.401,P=0.000)是老年急性脑梗死患者发生VBD的独立危险因素。结论年龄、男性、RC水平是老年急性脑梗死患者VBD的独立危险因素,高水平RC可能增加VBD的发生风险。Objective To investigate the correlation between the residual cholesterol(RC)level and vertebrobasilar dilatation(VBD)in elderly patients with acute cerebral infarction(ACI).Methods A total of 325 elderly AC1 patients admitted to Department of Neurology,Changzhou Second Peopee’s Hospital of Nanjing Medical University from January 2020 to July 2021 were recruited retrospectively.All of them underwent cranial MR1,CTA and biochemical test for plasma levels of TC,TG,LDL-C and HDL-C and other biochemical indicators.According to the imaging diagnostic criteria,they were divided into VBD group(52 cases)and non-VBD group(273 cases).Their clini-cal data were compared between the two groups,and the relationship between RC level and VBD was analyzed in the elderly AC1 patients.Results Significant differences were observed in age,sex,hypertension,history of smoking and TC and RC levels between the VBD group and non-VBD group(P<0.05,P<0.01).Multivariate logistic regression analysis showed that after adjus-ting the potential confounding factors,age (OR=1.126,95%CI:1.065-1.191,P=0.000),male (OR=4.163,95%CI:11.173-10.120,P=0.002),and RC level (OR=1.270,95%CI:1.151-1.401,P=0.000)were independent risk factors for VBD in elderly ACI patients.Conclusion Age,maee and RC level are independent risk factors for VBD in elderly ACI patients.High RC level may increase the risk of VBD.

关 键 词：脑梗死 椎底动脉供血不足 胆固醇 LOGISTIC模型 

分 类 号：R743.33[医药卫生—神经病学与精神病学]