胸膜外孤立性纤维性肿瘤的临床病理特征分析  

Clinical and Pathological Characteristics of Extrapleural Solitary Fibrous Tumor

作　　者：刘莹[1] 宋舒婕 吴琳[1] LIU Ying;SONG Shujie;WU Lin(Dept.of Pathology,The 3rd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650118,China)

机构地区：[1]昆明医科大学第三附属医院病理科,云南昆明650118

出　　处：《昆明医科大学学报》2024年第1期100-106,共7页Journal of Kunming Medical University

基　　金：云南省科技厅科技计划基金资助项目(202001AU070085,202201AY070001-154)。

摘　　要：目的 探讨胸膜外孤立性纤维性肿瘤的临床病理特征及鉴别诊断。方法 对26例胸膜外孤立性纤维性肿瘤样本进行HE及免疫组织化学染色,并结合临床及影像学资料进行综合分析。结果 孤立性纤维性肿瘤的组织学形态多样,典型者可见卵圆形或梭形细胞不规则排列,间质中可见粗大的胶原带、鹿角状血管及管周透明变性;免疫组化染色STAT-6、CD34、Bcl-2、CD99、SMA阳性率分别为96.2%、92.3%、92.3%、76.9%、26.9%。结论 SFT常见发生于胸膜,亦可发生于其它部位,其组织学特征和免疫组化表型有助于明确诊断,但当其发生于不常见的解剖部位时,应当对重点需要鉴别或排除的疾病加以认真细致的鉴别并综合判断其临床预后。Objective To investigate the clinical and pathological characteristics of the extrapleural solitary fibrous tumor and the relevant differential diagnosis.Methods HE and immunohistochemical staining were performed on 26 samples of isolated fibrous tumors outside the pleura,and a comprehensive analysis was conducted based on the clinical and imaging data.Results The histological morphology of isolated fibrous tumors was diverse,with typical cases showing the irregular arrangement of oval or spindle shaped cells.In the stroma,thick collagen bands,antler like blood vessels,and peritubular transparent degeneration could be seen.The immunohistochemical staining demonstrated that the positive rates of STAT-6、CD34、Bcl-2、CD99、SMA were 96.2%、92.3%、92.3%、76.9%and 26.9%,respectively.Conclusion SFT commonly occurs in the pleura and can also occur in other areas.Its histological characteristics and immunohistochemical phenotype help to clarify the diagnosis.However,when it occurs in uncommon anatomical sites,it is necessary to carefully and meticulously distinguish and comprehensively judge the clinical prognosis of key diseases that need to be distinguished or excluded..

关 键 词：胸膜外孤立性纤维性肿瘤 组织学形态 生物学行为 临床预后 

分 类 号：R365[医药卫生—病理学]