铁死亡在肝细胞癌中的研究进展  

Research progress on ferroptosis in hepatocellular carcinoma

作　　者：窦婷 朱向高 杨昊[2,3] Dou Ting;Zhu Xianggao;Yang Hao(Inner Mongolia Medical University,Huhhot 010010,Inner Mongolia China;Department of Radiotherapy,Affiliated Cancer Hospital of Inner Mongolia Medical University&Peking University Cancer Hospital(Inner Mongolia Campus),Huhhot 010020,Inner Mongolia,China;Key Laboratoy of Radiation Physics and Biology of Inner Mongolia Medical University,Huhhot 010020,Inner Mongolia,China;Department of radiotherapy,Peking University Cancer Hospital and Beijing Institute of Cancer Prevention and treatment,Beijing 100142,China;Key Laboratory of Pathogenesis and Transformation of Malignant Tumors of Ministry of Education,Peking University Cancer Hospital and Beijing Institute of Cancer Prevention and Control,Beijing 100142,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010010 [2]内蒙古医科大学附属肿瘤医院、北京大学肿瘤医院内蒙古医院放射治疗中心,内蒙古呼和浩特010020 [3]内蒙古医科大学放射物理与放射生物重点实验室,内蒙古呼和浩特010020 [4]北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科,北京1001425 [5]北京大学肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《中国肝脏病杂志（电子版）》2023年第4期6-10,共5页Chinese Journal of Liver Diseases：Electronic Version

基　　金：国家自然科学基金项目(81860534、82260481);内蒙古自然科学基金项目(2021MS08152);内蒙古自治区科技计划项目(2019GG039、2019GG086、2021GG0167);内蒙古自治区高等学校青年科技英才支持计划项目(NJYT22004);内蒙古自治区卫生健康科技计划项目(202201356);内蒙古医科大学重点项目(YKD2022ZD002、YKD2022XK009、YKD2022XK014、PIKY2023030);内蒙古自治区硕士研究生科研创新项目(S20231187Z)。

摘　　要：铁死亡是一种区别于细胞凋亡的程序性细胞死亡形式,主要发生机制是二价铁的增加或体内抗氧化系统失衡,产生大量脂质过氧化物,最后引发细胞死亡。铁死亡参与多种癌症的发生,在癌症的发病机制中发挥重要作用。肝细胞癌(hepatocellular carcinoma,HCC)是中国最常见的恶性肿瘤,近年来大量研究表明铁死亡在HCC中的发生机制和治疗不敏感以及获得性耐药方面发挥至关重要的作用,得到众多研究人员的广泛关注。本文总结了铁死亡在HCC中的主要调节通路、关键调节因子以及在HCC治疗中的潜在应用,为HCC的精准治疗提供新思路。Ferroptosis is a form of programmed cell death which is different from apoptosis,the main mechanism is the increase of bivalent iron or the imbalance of antioxidant system in vivo,which produces a large number of lipid peroxides and finally leads to cell death.Ferroptosis is involved in the occurrence of a variety of cancers and is considered to play an important role in the pathogenesis of cancer.Hepatocellular carcinoma(HCC)is the most common malignant tumor in China.In recent years,a large number of studies showed that ferroptosis played an important role in the pathogenesis,treatment insensitivity and acquired drug resistance of HCC,which had been widely concerned by many researchers.This paper summarized the main regulatory pathways and key regulatory factors of ferroptosis in HCC,as well as its potential application in the treatment of HCC,so as to provide new ideas for the accurate treatment of HCC.

关 键 词：铁死亡 肝细胞癌 谷胱甘肽过氧化物酶4 肿瘤治疗 

分 类 号：R735.7[医药卫生—肿瘤]