肝再生细胞来源及调控机制的研究进展  

Research progress on the sources and regulatory mechanisms of liver regenerative cells

作　　者：叶晓琳 刘云飞 庞明泉[3] 王海久[3] 任利[4] 侯立朝[3] 于文昊 王志鑫[3] 樊海宁[3] Ye Xiaolin;Liu Yunfei;Pang Mingquan;Wang Haijiu;Ren Li;Hou Lizhao;Yu Wenhao;Wang Zhixin;Fan Haining(Graduate School of Qinghai University,Xining Qinghai Province 810000,China;Affiliated Hospital of Qinghai University,Xining Qinghai Province 810000,China;Department 2 of General Surgery(Hepatobiliary and Pancreatic),Affiliated Hospital of Qinghai University,Xining Qinghai Province 810000,China;Department 1 of General Surgery(Hepatobiliary and Pancreatic),Affiliated Hospital of Qinghai University,Xining Qinghai Province 810000,China)

机构地区：[1]青海大学研究生院,青海西宁810000 [2]青海大学附属医院,青海西宁810000 [3]青海大学附属医院普通外科学二科(肝胆胰),青海西宁810000 [4]青海大学附属医院普通外科学一科(肝胆胰),青海西宁810000

出　　处：《中华普外科手术学杂志（电子版）》2024年第1期96-99,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：2023年国家临床重点专科建设项目(青卫健办[2023]25号)。

摘　　要：肝再生(LR)是肝细胞和分子之间的一组复杂机制,其中肝脏修复的启动、增殖和终止过程受到调节。肝脏在面对各类肝脏疾病以及治疗措施,其再生能力受到明显影响。另外,肝脏疾病是否能够缓解甚至治愈在很大程度上取决于肝细胞的再生能力,以实现肝功能的恢复。探索LR的发生机制及相关细胞来源,对于在不同病理模式下加速肝功能恢复,制定治疗策略具有重要意义。尽管LR已经得到了广泛的研究,但要充分理解仍然存在许多挑战。现就肝再生发生机制进行综述,以期对肝脏疾病的变化有一个新的认识,为肝脏疾病的治疗提供新的方向。Liver regeneration(LR)is a complex set of mechanisms between liver cells and molecules in which the initiation,proliferation,and termination processes of liver repair are regulated.In the face of various liver diseases and treatment measures,the liver's regenerative capacity is significantly affected.In addition,whether liver diseases can be alleviated or even cured depends to a large extent on the regenerative ability of liver cells to achieve the recovery of liver function.Exploring the pathogenesis of LR and the related cell sources is of great significance for accelerating the recovery of liver function under different pathological modes and formulating therapeutic strategies.Although LR has been extensively studied,many challenges remain to fully understand it.This article reviews the mechanism of liver regeneration in order to have a new understanding of the changes of liver diseases and provide a new direction for the treatment of liver diseases.

关 键 词：肝再生 肝细胞 机制 调控 

分 类 号：R575[医药卫生—消化系统]