角膜胶原交联术在较薄型圆锥角膜治疗中的研究进展  

Progress of corneal collagen cross-linking for the treatment of thin keratoconic corneas

作　　者：周玉红 邓应平[1] ZHOU Yuhong;DENG Yingping(Department of Ophthalmology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China)

机构地区：[1]四川大学华西医院眼科,四川成都610041

出　　处：《山东大学耳鼻喉眼学报》2024年第1期115-121,共7页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：四川省科技厅重点研发项目(2021YFSO221)。

摘　　要：角膜胶原交联术通过增加角膜硬度及生物力学稳定性可有效阻止或延缓圆锥角膜病情的进展。为避免术中紫外线能量对角膜内皮细胞及眼内组织造成不可逆的损伤,标准角膜胶原交联方案要求最薄点角膜基质厚度≥400μm,这将较薄型圆锥角膜排除在外。为打破角膜厚度这一限制因素,诸多学者对标准角膜胶原交联方案不断改进,论文回顾总结了针对较薄型圆锥角膜的改良角膜胶原交联方案。Corneal collagen cross-linking can effectively prevent or delay the progression of keratoconus by increasing corneal stiffness and biomechanical stability.To avoid irreversible damage to corneal endothelial cells and intraocular tissues caused by ultraviolet radiation,the standard protocol requires that the thinnest cornea stroma must have a minimal thickness of 400μm,which excludes the thin keratoconic corneas.In order to break this limitation,plentiful scholars have being ameliorated the standard protocol.So,this article reviews and summarizes the modified corneal collagen cross-linking protocols for thin keratoconic corneas.

关 键 词：圆锥角膜 角膜胶原交联 较薄型圆锥角膜 核黄素 治疗 

分 类 号：R772.23[医药卫生—眼科]