静息态功能磁共振成像在血管性认知障碍患者默认网络研究中的应用进展  

Application Progress of Resting-State Functional Magnetic Resonance Imaging in Study of Default Mode Network in Patients with Vascular Cognitive Impairment

作　　者：王雪[1] 牛亚利[1] 王婧[1] 陈晓娜[1] 万春晓[1] WANG Xue;NIU Yali;WANG Jing;CHEN Xiaona;WAN Chunxiao(Department of Rehabilitation Medicine,Tianjin Medical University General Hospital,Tianjin,300052)

机构地区：[1]天津医科大学总医院康复医学科,天津市300052

出　　处：《中国医疗器械杂志》2024年第1期51-56,共6页Chinese Journal of Medical Instrumentation

基　　金：国家自然科学基金青年项目(81802241);天津市医学重点学科(专科)建设项目(TJYXZDXK-060B)。

摘　　要：血管性认知障碍是由脑血管疾病导致的一种从轻度认知功能障碍至痴呆的综合征,由于缺乏敏感性和特异性生物标志物,早期不易鉴别和诊断。血管性认知障碍患者脑网络连接异常的脑区多位于默认网络,其异常变化的功能连接与患者的认知障碍程度相关。静息态功能磁共振成像技术是一种常用的检测静息态大脑内在活动的方法,应用静息态磁共振不同分析技术探索血管性认知障碍患者默认网络异常变化有助于深入研究血管性认知障碍的发病机制,并提供客观的影像依据。该文主要综述静息态功能磁共振成像技术在血管性认知障碍患者默认网络研究中的应用成果,为血管性认知障碍的精准诊断和评估提供新思路。Vascular cognitive impairment(VCI)is a group of syndromes ranging from mild cognitive impairment to dementia caused by cerebrovascular disease,due to the lack of sensitivity and specific biomarkers,it is difficult to identify and diagnose early.Abnormal connectivity is observed in brain regions of patients with vascular cognitive disorders,locates mainly in the default mode network(DMN),and changes in their abnormal functional connectivity correlated with the degree of patients'cognitive impairment.Restingstate functional magnetic resonance imaging(rs-fMRI)is a commonly used method to detect the internal activity of the brain at resting state.The use of various rs-fMRI to study abnormal changes in the DMN in patients with VCI is useful to further investigate the pathogenesis of VCI and provide an objective basis for imaging.This article mainly reviews the application of rs-fMRI in the DMN in patients with VCI,bringing new perspectives for the correct diagnosis and assessment of VCI.

关 键 词：静息态功能磁共振成像 血管性认知障碍 默认网络 

分 类 号：R318[医药卫生—生物医学工程]