鼠李糖乳杆菌对海马GABA受体表达及食管癌术后认知功能的影响  

Effects of Lactobacillus Rhamnose on expression of GABA receptor in hippocampus and cognitive function after esophageal cancer surgery

作　　者：余亚飞 高雁华[1] YU Yafei;GAO Yanhua(Dept.of Anesthesiology,Anyang People′s Hospital,Anyang 455000,China)

机构地区：[1]安阳市人民医院麻醉科,河南安阳455000

出　　处：《华夏医学》2023年第6期23-27,共5页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ202101126)。

摘　　要：目的:分析长期应用鼠李糖乳杆菌对海马γ-氨基丁酸(GABA)受体表达的影响,及对食管癌术后认知功能障碍的防治效果。方法:选取119例食管癌患者,按照不同的治疗方法分为观察组69例和对照组50例。观察组在食管癌根治术前应用鼠李糖乳杆菌治疗,对照组直接采用食管癌根治术治疗,比较两组不同时间点的GABA受体表达情况,认知功能评分,以及GABA受体水平与术后认知评分及认知障碍发生率的相关性。结果:术前4周、术前1周、术后24 h,观察组GABA受体水平低于对照组,差异有统计学意义(P<0.05)。术后,观察组的MMSE、MoCA评分均高于对照组(P<0.05)。术后,观察组的认知障碍发生率低于对照组(P<0.05)。经Spearman相关性分析,GABA受体水平与食管癌术后MMSE、MoCA评分负相关,与认知障碍发生率正相关。结论:长期应用鼠李糖乳杆菌能有效拮抗海马GABA受体表达水平,对改善食管癌术后认知功能、降低认知障碍发生风险有重要意义。Objective:To analyze the effects of long-term application of Lactobacillus Rhamnose on hippocampusγ-aminobutyric acid(GABA)receptor expression and its preventive and therapeutic effects on postoperative cognitive impairment in esophageal cancer.Methods:119 patients with esophageal cancer were divided into the observation group(69 cases)and control group(50 cases)according to different therapeutic schemes.The observation group were treated with Lactobacillus Rhamnose before radical resection of esophageal cancer.The control group were directly treated with esophageal cancer radical surgery.The expression of GABA receptors,cognitive function scores,and the correlation between GABA receptor levels and postoperative cognitive scores and the incidence of cognitive impairment were compared between two groups at different time points.Results:At 4 weeks before surgery,1 week before surgery,and 24 hours after surgery,the GABA receptor levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After surgery,the MMSE and MoCA levels in the observation group were higher than those in the control group(P<0.05).After surgery,the incidence of cognitive impairment in the observation group was lower than that in the control group(P<0.05).According to Spearman correlation analysis,GABA receptor levels were negatively correlated with postoperative MMSE and MoCA scores in esophageal cancer,and positively correlated with the incidence of cognitive impairment.Conclusion:Long term application of Lactobacillus Rhamnose can effectively antagonize the expression of GABA receptor in hippocampus,which is of great significance in improving cognitive function and reducing the risk of cognitive impairment after esophageal cancer surgery.

关 键 词：鼠李糖乳杆菌 Γ-氨基丁酸受体 食管癌 认知障碍 相关性分析 

分 类 号：R735.1[医药卫生—肿瘤]