血清甘胆酸、总胆汁酸在肝硬化中的表达及其对肝癌的预测价值  

Expression of Serum Cholyglycine and Total Bile Acid in Liver Cirrhosis and Their Predictive Value for Liver Cancer

作　　者：王斌 曾晖 邱利 WANG Bin;ZENG Hui;QIU Li(Wuhan Seventh Hospital,Wuhan 430061,China;不详)

机构地区：[1]武汉市第七医院,湖北武汉430061

出　　处：《中外医学研究》2023年第34期71-74,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨血清甘胆酸(cholyglycine,CG)、总胆汁酸(total bile acid,TBA)在肝硬化中的表达及其对肝癌的预测价值。方法:选取2021年6月—2022年6月武汉市第七医院收治的68例肝硬化患者作为观察组,另选取同期收治的68例病毒性肝炎患者作为对照组,以及同期68例健康体检者作为健康组。检测三组血清CG、TBA水平。对观察组患者开展半年随访,根据是否进展为肝癌将其分为肝癌组及非肝癌组,收集两组一般资料。比较三组及观察组不同疾病分期患者血清CG、TBA水平。统计观察组分组情况,并比较肝癌组及非肝癌组一般资料、血清CG、TBA水平。分析血清CG、TBA预测肝癌的临床价值。结果:观察组血清CG、TBA水平均高于对照组、健康组,差异有统计学意义(P<0.05)。失代偿期患者血清CG、TBA水平均高于代偿期患者,差异有统计学意义(P<0.05)。随访半年,68例肝硬化患者中共12例进展为肝癌,发生率为17.65%(12/68);肝癌组失代偿期占比高于非肝癌组,肝硬化病程长于非肝癌组,差异有统计学意义(P<0.05)。肝癌组血清CG、TBA水平均高于非肝癌组,差异有统计学意义(P<0.05)。绘制受试者工作特征(ROC)曲线,CG、TBA及联合检测预测肝癌的曲线下面积(AUC)分别为0.813、0.832、0.959,联合检测预测价值更高。结论:血清CG、TBA在肝硬化中存在较高表达,能够良好评估肝硬化病情,且对肝癌的发生具有一定预测价值,联合检测预测价值更高。Objective:To investigate the expression of serum cholyglycine(CG)and total bile acid(TBA)in liver cirrhosis and their predictive value for liver cancer.Method:Sixty-eight patients with liver cirrhosis admitted to Wuhan Seventh Hospital from June 2021 to June 2022 were selected as the observation group,68 patients with viral hepatitis admitted at the same period were selected as the control group,and 68 healthy physical examiner patients at the same period were selected as the health group.Serum CG and TBA levels were detected in three groups.Patients in the observation group were followed up for half a year,and they were divided into liver cancer group and non-liver cancer group according to whether they developed liver cancer.General data of the two groups were collected.The serum CG and TBA levels of the three groups and patients with different disease stages in observation group were compared.The general information,serum CG and TBA levels of liver cancer group and non-liver cancer group were compared.The clinical value of serum CG and TBA in predicting liver cancer was analyzed.Result:Serum CG and TBA levels in observation group were higher than those in control group and healthy group,and the differences were statistically significant(P<0.05).The levels of serum CG and TBA in the decompensated stage were higher than those in the compensation stage,and the differences were statistically significant(P<0.05).The 68 patients with liver cirrhosis were followed up for six months,and 12 cases developed into liver cancer,with the incidence was 17.65%(12/68).The proportion of decompensated period in the liver cancer group was higher than that in the non-liver cancer group,and the duration of liver cirrhosis was longer than that in the non-liver cancer group,and the differences were statistically significant(P<0.05).The levels of serum CG and TBA in liver cancer group were higher than those in non-liver cancer group,and the differences were statistically significant(P<0.05).The receiver operating characteristic(ROC)cu

关 键 词：肝硬化 肝癌 甘胆酸 总胆汁酸 表达 预测价值 

分 类 号：R735.7[医药卫生—肿瘤]