胎儿NT超声检测联合颜面轮廓超声指标筛查在唐氏综合征诊断中的应用价值  

Application Value of Fetal NT Ultrasound Combined with Facial Contour Ultrasound Index Screening in the Diagnosis of Down Syndrome

作　　者：沈春明 戴斌 SHEN Chunming;DAI Bin(Jiangsu Shengze Hospital,Suzhou 215228,China;不详)

机构地区：[1]江苏盛泽医院,江苏苏州215228

出　　处：《中外医学研究》2024年第1期63-67,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨胎儿颈后透明层(NT)超声检测联合颜面轮廓超声指标筛查在唐氏综合征诊断中的应用价值。方法:回顾性选取2019年1月—2023年6月在江苏盛泽医院进行胎儿唐氏综合征筛查并确诊的101例孕妇为观察组,并选取同期胎儿筛查结果正常的80例孕妇作为对照组。比较两组胎儿NT厚度、额-上颌(FMF)角、上颌-鼻根-下颌(MNM)角和鼻前组织厚度与鼻骨长度比值(PT/NBL)及各指标诊断结果,并绘制受试者工作曲线(ROC)分析NT厚度单独、联合FMF角及联合FMF角和PT/NBL的诊断效能。结果:两组MNM角比较,差异无统计学意义(P>0.05),观察组NT厚度、FMF角及PT/NBL显著大于对照组,差异有统计学意义(P<0.05);观察组NT厚度增加,FMF角增大和PT/NBL增大的检出率均显著高于对照组,差异有统计学意义(P<0.05);MNM角减小的检出率与对照组比较,差异无统计学意义(P>0.05)。NT厚度、FMF角和PT/NBL三者联合诊断唐氏综合征的曲线下面积(AUC)为0.940,明显高于NT厚度诊断(0.878)和NT厚度联合FMF角诊断(0.887)。结论:NT增厚、FMF角增大、PT/NBL增大与胎儿唐氏综合征有关,与NT厚度单独和NT厚度联合FMF角相比,联用NT厚度、FMF角和PT/NBL三项参数进行胎儿唐氏综合征筛查具有较高的诊断价值。Objective:To explore the application value of fetal nuchal translucency(NT)ultrasound combined with facial contour ultrasound index screening in the diagnosis of Down syndrome.Method:A retrospective study was conducted,selecting 101 pregnant women who underwent fetal Down syndrome screening and were diagnosed at Jiangsu Shengze Hospital from January 2019 to June 2023 as the observation group.Additionally,80 pregnant women with normal fetal screening results during the same period were selected as the control group.The study compared the two groups in terms of fetal ultrasound NT thickness,the frontal-maxillary facial(FMF)angle,the maxillary-nasal-mandibular(MNM)angle,and the prenasal thickness to nasal bone length ratio(PT/NBL),as well as the diagnostic outcomes of each indicator.Receiver operating characteristic(ROC)curves were constructed to analyze the diagnostic efficiency of NT thickness alone,combined with the FMF angle,and combined with both the FMF angle and PT/NBL.Result:There was no significant difference in MNM angle between the two groups(P>0.05).The NT thickness,FMF angle and PT/NBL in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The detection rates of increased NT thickness,FMF angle and PT/NBL in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The detection rate of decreased MNM angle did not show a statistically significant difference compared to the control group(P>0.05).The combined diagnostic approach of NT thickness,FMF angle,and PT/NBL for Down syndrome had an area under the curve(AUC)of 0.940,which was significantly higher than the diagnosis using NT thickness(0.878)and the combined diagnosis of NT thickness and FMF angle(0.887).Conclusion:Increased NT thickness,enlarged FMF angle,and increased PT/NBL are associated with fetal Down syndrome.Compared to using NT thickness alone and the combination of NT thickness w

关 键 词：胎儿 唐氏综合征 颈后透明层超声 颜面轮廓超声 诊断 

分 类 号：R714.5[医药卫生—妇产科学]