膜联蛋白A11在肿瘤中的研究进展  

Research progress of annexin A11 in tumors

作　　者：徐宁(综述) 李勇(审校)[1] XU Ning;LI Yong(Stomatological Hospital of Chongqing Medical University/Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences/Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education,Chongqing 401147,China)

机构地区：[1]重庆医科大学附属口腔医院/口腔疾病与生物学重庆市重点实验室/重庆市高校市级口腔生物医学工程重点实验,重庆401147

出　　处：《现代医药卫生》2024年第3期472-476,481,共6页Journal of Modern Medicine & Health

摘　　要：膜联蛋白(ANX)是以钙离子(Ca^(2+))浓度依赖性方式结合膜磷脂的细胞内蛋白质家族,在各种细胞类型中广泛表达。ANXA11是Ca^(2+)调节的磷脂依赖性和膜结合ANX多基因家族成员之一。既往研究表明,ANXA11在细胞分裂、Ca^(2+)信号传导、囊泡运输、细胞凋亡中均具有重要作用。近年来,有研究表明,ANXA11的失调和突变与系统性自身免疫性疾病和癌症的发展、化疗耐药性和复发等有关。ANXA11在多种肿瘤中高表达,可作为促癌基因参与肿瘤的发生、发展,有望成为一个癌症诊断、治疗及预后的潜在分子标志物。该文就近年来ANXA11的生物学功能及在肿瘤中的研究进展进行了回顾和综述。Annexin(ANX)are a family of intracellular proteins that bind membrane phospholipids in a calcium ion(Ca^(2+) )-concentration-dependent manner and are widely expressed in various cell types.ANXA11 is a member of the Ca^(2+) -regulated phospholipid-dependent and membrane-bound ANX multigene family.Previous studies have shown that ANXA11 has important roles in cell division,Ca^(2+) signaling,vesicle trafficking,and apoptosis.Recent studies have shown that dysregulation and mutation of ANXA11 are associated with the development of systemic autoimmune diseases and cancers,chemotherapy resistance,and recurrence,etc.ANXA11,which is highly expressed in a variety of tumors,can be involved in tumorigenesis and development as a pro-carcinogenic gene,and is expected to be a potential molecular marker for cancer diagnosis,treatment,and prognosis.This article reviews the biological function and the research progress of ANXA11 in tumors in recent years.

关 键 词：膜联蛋白A11 肿瘤 肿瘤微环境 综述 

分 类 号：R73[医药卫生—肿瘤]