c-Myc、CDK12在胃癌组织中的表达及临床意义  

Expression and clinical significance of c-Myc and CDK12 in gastric carcinoma tissue

作　　者：杨雪[1] 程园园[1] 田瑞华[1] YANG Xue;CHENG Yuan-yuan;TIAN Rui-hua(Chemotherapy Department,High-Tech Hospital of Tai'an Central Hospital,Tai'an 271000,China)

机构地区：[1]泰安市中心医院高新院区化疗科,271000

出　　处：《中国实用医药》2024年第2期11-14,共4页China Practical Medicine

摘　　要：目的 探讨胃癌组织中c-Myc、细胞周期蛋白依赖性激酶12(CDK12)表达及其与患者临床特征及预后的关系。方法 收集80例胃癌患者的胃癌组织和癌旁组织标本,采用免疫组化法检测标本中的c-Myc、CDK12表达水平。比较胃癌组织和癌旁组织中c-Myc、CDK12阳性表达情况;分析胃癌组织中c-Myc、CDK12阳性表达与患者临床病理特征的关系;分析c-Myc与CDK12阳性表达的相关性,胃癌组织中c-Myc、CDK12阳性表达与胃癌患者预后的关系。结果 胃癌组织中c-Myc、CDK12阳性表达率(77.5%、87.5%)均明显高于癌旁组织(13.8%、15.0%)(P<0.05)。不同年龄、性别、肿瘤最大直径患者胃癌组织中c-Myc、CDK12阳性表达率比较差异无统计学意义(P>0.05);中低分化、Ⅲ~Ⅳ期、侵犯浆膜、有淋巴结转移患者胃癌组织中c-Myc和CDK12阳性表达率分别为88.0%、87.0%、88.9%、90.0%和94.0%、92.6%、97.2%、100.0%,均明显高于高分化、Ⅰ~Ⅱ期、未侵犯浆膜、无淋巴结转移患者胃癌组织的60.0%、57.7%、68.2%、70.0%和76.7%、76.9%、79.5%、80.0%(P<0.05)。相关分析发现,c-Myc、CDK12在胃癌组织中的表达呈正相关性(r=0.487,P=0.016<0.05)。胃癌组织中c-Myc、CDK12阳性患者的3年生存率分别为19.4%、21.4%,均明显低于c-Myc、CDK12阴性患者的55.6%、70.0%(P<0.05)。结论 c-Myc、CDK12在胃癌组织中异常高表达,两者呈正相关性,并与肿瘤的TNM分期、分化程度、肿瘤侵袭深度及淋巴结转移有关,对患者的预后有明显影响,通过检测两者水平可能评估胃癌患者的预后。Objective To investigate the expression of c-Myc and cyclin-dependent kinase 12(CDK12in gastric carcinoma tissue and their correlation with clinical features and prognosis.Methods 80 specimens of gastric carcinoma and para-carcinoma tissues were collected.The expression of c-Myc and CDK12 was detected by immunohistochemistry.The positive expressions of c-Myc and CDK12 in gastric carcinoma tissues and para-carcinoma tissues were compared,and the correlation between positive expressions of c-Myc and CDK12 in gastric para-carcinoma tissues and clinicopathological features of patients was analyzed,as well as the correlation between positive expressions of c-Myc and CDK12 in gastric carcinoma tissues and the prognosis of patients.Results The positive expression rates of c-Myc and CDK12 in gastric carcinoma tissues(77.5%,87.5%) were significantly higher than those in para-carcinoma tissues(13.8%,15.0%)(P<0.05).There was no statistically significant difference in the positive expression rates of c-Myc and CDK12 in gastric carcinoma tissues of patients with different age,gender and maximum tumor diameter(P>0.05).The positive expression rates of c-Myc and CDK12 in gastric carcinoma tissue of patients with middle-low differentiation,stage Ⅲ-Ⅳ,serosa invasion and lymph node metastasis were 88.0%,87.0%,88.9%,90.0% and 94.0%,92.6%,97.2%,100.0%,which were significantly higher than those of 60.0%,57.7%,68.2%,70.0% and 76.7%,76.9%,79.5%,80.0%in gastric carcinoma tissue of patients with high differentiation,stage Ⅰ-Ⅱ,no serosa invasion and no lymph node metastasis(P< 0.05).Correlation analysis showed that the expression of c-Myc and CDK12 were positively correlated with each other(r=0.487,P=0.016<0.05).The 3-year survival rate of patients with positive expression of c-Myc and CDK12 was significantly lower than that of patients with negative expression of c-Myc and CDK12(P<0.05).Conclusion The expression of c-Myc and CDK12 is abnormally high in gastric carcinoma tissues,and the expression of c-Myc and CDK12 is positively c

关 键 词：胃癌 癌基因 C-MYC 细胞周期蛋白依赖性激酶12 预后 

分 类 号：R735.2[医药卫生—肿瘤]