成年烟雾病患者的模糊决策功能研究  

Capacity of decision-making under ambiguity in adult patients with moyamoya disease

作　　者：邬攀 聂佳佳 蒿玉兴 李超[2] 汪凯[1,3,4] 卫玲[1,3,4] Wu Pan;Nie Jiajia;Hao Yuxing;Li Chao;Wang Kai;Wei Ling(Dept of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Dept of Neurosurgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022 [2]安徽医科大学第一附属医院神经外科,合肥230022 [3]安徽医科大学第一附属医院认知与神经精神疾病安徽省重点实验室,合肥230022 [4]安徽医科大学第一附属医院神经精神疾病与心理健康协同创新中心,合肥230022

出　　处：《安徽医科大学学报》2023年第12期2124-2128,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81870918);安徽省转化医学研究院科研基金(编号:2022zhyx-B11)。

摘　　要：目的探索成年烟雾病(MMD)患者的模糊决策功能是否受损及其与执行功能的相关性。方法利用神经心理学量表测试41例成年MMD患者(MMD组)和41例健康对照(HC组)的执行功能,采用爱荷华博弈任务(IGT)测试两组被试者的模糊决策功能,并对两组数据进行差异性分析和相关性分析。结果①IGT任务中,MMD组总有利选择次数明显低于HC组(Z=-2.782,P<0.01),MMD组总不利选择次数明显高于HC组(Z=-2.782,P<0.01)。方差分析结果显示,MMD组在Block4、Block5的净剩值分别低于HC组的Block4、Block5(t=-3.433,P=0.001;t=-5.271,P<0.001),Block1的净剩值高于HC组的Block1(t=2.715,P=0.008)。②Spearman相关性分析显示IGT净剩值、总有利次数、总不利次数与执行功能之间无明显相关性。结论成年烟雾病患者可能存在模糊决策功能受损,且与执行功能无明显相关。Objective To explore whether the capacity of decision-making under ambiguity in adult patients with moyamoya disease(MMD)is impaired and its association with executive function.Methods Neuropsychological scales were used to measure the executive function of forty-one adult patients with MMD and forty-one healthy controls(HC),The Iowa Gambling Task(IGT)was utilized to study the capacity of decision-making under ambiguity of the two groups.Correlation analysis was performed between the two types of data.Results①The total number of favorable choices in the MMD group was significantly lower than that in the HC group,with a statistically significant difference(Z=-2.782,P<0.01),and the total number of unfavorable choices was significantly higher than that of the controls,with a statistically significant difference(Z=-2.782,P<0.01).The results of ANOVA showed that the net residual value of Block4 and Block5 in MMD group was lower than that of Block4 and Block5 in HC group,respectively,and the differences were statistically significant(t=-3.433,P=0.001;t=-5.271,P<0.001),the net residual value of Block1 was higher than that of Block1 in HC group,the difference was statistically significant(t=2.715,P=0.008).②Spearman correlation analysis revealed no association between the net score of IGT,the total number of favorable choices,the total number of unfavorable choices,and executive function.Conclusion The capacity of decision-making under ambiguity in adult patients with MMD is impaired possibly,which is not correlated with executive cognition.

关 键 词：烟雾病 模糊决策 执行功能 脑血管疾病 爱荷华博弈任务 

分 类 号：R743.3[医药卫生—神经病学与精神病学]