体内药物分析技术在临床药学工作中的应用进展  

Application progress on in vivo drug analysis technique in clinical pharmacy

作　　者：陈亭如 毛士龙[2] CHEN Tingru;MAO Shilong(School of Medicine,Shanghai University,Shanghai 200444,China;Department of Pharmacy,Shanghai Xuhui District Central Hospital,Shanghai 200031,China)

机构地区：[1]上海大学医学院,上海200444 [2]上海市徐汇区中心医院药剂科,上海200031

出　　处：《药学实践与服务》2024年第2期60-65,共6页Journal of Pharmaceutical Practice and Service

摘　　要：目的探讨体内药物分析技术在临床药学工作中的应用进展。方法查阅相关文献,对临床样本的特点、临床常用的体内药物分析方法、体内药物分析在临床药学中的应用以及现存的问题进行综述。结果和结论近年来,随着临床个体化治疗、精准治疗的需求增大,以及分析技术的不断发展,体内药物分析技术广泛地应用于临床药学工作中,成为促进临床合理用药、提高个体化治疗水平、减少药品不良反应发生的重要辅助技术之一。但在实际应用中,还存在血液采样的侵入性阻碍采样、药物监测结果解释能力弱和临床检测方法等仍有待完善的问题。这些问题应当引起重视,并在后续的研究和应用中不断改善和解决。Objective To explore the progress on the application of in vivo drug analysis techniques in clinical pharmacy work.Methods Relevant literature was reviewed to provide an overview of the characteristics of clinical samples,common in vivo drug analysis methods used in the clinic,the application and existing problems of in vivo drug analysis in clinical pharmacy.Results and Conclusion In recent years,with the increasing demand for individualized and precise treatment in clinical practice and the continuous development of analytical techniques,in vivo drug analysis techniques have been widely used in clinical pharmacy work,which have become one of the important auxiliary techniques to promote rational clinical drug use,improve individualized treatment and reduce the occurrence of adverse reactions.However,in the actual application,there were still problems such as the invasive blood sampling that hinders sampling,the weak ability to interpret drug monitoring results and clinical testing methods that still need to be improved.These problems should be taken seriously and continuously improved and solved in the subsequent research and application.

关 键 词：体内药物分析技术 临床药学 治疗药物监测 应用 

分 类 号：R917[医药卫生—药物分析学]