间充质干细胞来源外泌体在抗肝纤维化机制方面的研究进展  

Research progress of mesenchymal stem cell-derives exosomes on the mechanism of anti-hepatic fibrosis

作　　者：董旭 尹伟 许明晓 王歆妤 梁雪松 DONG Xu;YIN Wei;XU Mingxiao;WANG Xinyu;LIANG Xuesong(Department of Infectious Diseases,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院感染科,上海200433

出　　处：《传染病信息》2023年第5期463-468,共6页Infectious Disease Information

基　　金：上海市自然科学基金项目(20ZR1456900)。

摘　　要：间充质干细胞来源广泛、相对容易获得,主要通过分泌的外泌体发挥作用。间充质干细胞来源外泌体(mesenchymal stem cell-derived exosomes,MSC-exo)在细胞间的物质和信息传递中起重要作用,能通过多种机制抗肝纤维化(liver fibrosis,LF),在疾病治疗领域具有广阔的应用前景。本文就MSC-exo在抗LF机制方面的研究进行综述,为LF的无细胞移植提供新思路。Mesenchymal stem cells are widely sourced,relatively easy to obtain,and function mainly through secreted exosomes.Mesenchymal stem cell-derived exosomes(MSC-exo)play an important role in the transmission of substances and information between cells,and can inhibit liver fibrosis(LF)through various mechanisms,which has a broad application prospect in the field of disease treatment.This article reviews the research of MSC-exo in the mechanism of LF,and provides a new idea for cell-free transplantation of LF.

关 键 词：间充质干细胞 外泌体 肝纤维化 抗纤维化 无细胞移植 机制 肝星状细胞 旁分泌作用 组织再生 再生医学 

分 类 号：R575.2[医药卫生—消化系统]