早期胚胎停育患者绒毛染色体结果分析及临床意义  

Analysis and Clinical Significance of Chorionic Chromosome Results of 369 Patients with Early Embryo Abortion

作　　者：李玲玲 刘月芳 潘琼[2] LI Lingling;LIU Yuefang;PAN Qiong(Department of Family Planning,Yangzhou University School of Medicine Affiliated Huai'an City Maternal and Child Health Hospital,Huai'an,Jiangsu 223000;Department of Medical Genetics and Prenatal Diagnosis,Yangzhou University School of Medicine Affiliated Huai'an City Maternal and Child Health Hospital,Huai'an,Jiangsu 223000)

机构地区：[1]扬州大学医学院附属淮安市妇幼保健院计划生育科,江苏淮安223000 [2]扬州大学医学院附属淮安市妇幼保健院医学遗传产前诊断科,江苏淮安223000

出　　处：《智慧健康》2023年第26期43-47,共5页Smart Healthcare

基　　金：江苏省妇幼健康科研项目《先天性肛门直肠畸形的基因组拷贝数变异和基因突变分析》(项目编号:F201670)。

摘　　要：目的探讨早期胚胎停育的影响因素。方法应用染色体微阵列分析技术(chromosomal microarray analysis,CMA)对2015年10月—2021年3月于淮安市妇幼保健院就诊的388例早期胚胎停育患者绒毛组织进行检测,了解染色体异常情况。结果388例早期胚胎停育标本中,369例获得明确结果,其中染色体异常231例(62.60%)。染色体异常中最常见的为非整倍体,占异常染色体比例72.29%(167/231),其余较为常见的染色体异常主要包括多倍体(34例)和拷贝数变异(27例)。结论染色体异常是早期胚胎停育的主要影响因素。Objective To explore influencing factors of early embryo suspension.Methods The paper detected chorionic villi of 388 patients with early embryo abortion in Huai'an City Maternal and Child Health Hospital from October 2015 to March 2021 with Chromosomal microarray analysis(CMA),to understand chromosomal abnormalities.Results Among 388 samples of early embryo suspension,369 showed clear results,including 231 cases of chromosomal abnormalities(62.60%,231/369).the most common chromosomal abnormality was aneuploidy,accounting for 72.29%(167/231)of abnormal chromosomes.the other common chromosomal abnormalities mainly included polyploidy(34 cases)and copy number variation(27 cases).Conclusion Chromosome abnormalities are main influencing factor for early embryo suspension.

关 键 词：早期胚胎停育 染色体异常 CMA 

分 类 号：R714.2[医药卫生—妇产科学] R440[医药卫生—临床医学]