Comparison of clinical efficacy between LAPS and ALPPS in the treatment of hepatitis B virus-related hepatocellular carcinoma  

作　　者：Zebin Chen Shunli Shen Wenxuan Xie Junbin Liao Shiting Feng Shaoqiang Li Jiehui Tan Ming Kuang 

机构地区：[1]Centre of Hepato-Pancreato-Biliary Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China [2]Department of Diagnostic Radiology,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China [3]Department of Hepatobiliary Surgery,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P.R.China

出　　处：《Gastroenterology Report》2023年第1期477-485,共9页胃肠病学报道（英文）

基　　金：supported by China National Funds for Distinguished Young Scientists[No.81825013].

摘　　要：Background:Insufficient post-operative future liver remnant(FLR)limits the feasibility of hepatectomy for patients.Staged hepatectomy is an effective surgical approach that can improve the resection rate of hepatocellular carcinoma(HCC).This study aimed to compare the safety and efficacy of laparoscopic microwave ablation and portal vein ligation for staged hepatectomy(LAPS)and classical associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in the treatment of hepatitis B virus(HBV)-related HCC.Methods:Clinical data of patients with HBV-related HCC who underwent LAPS or ALPPS in our institute between January 2017 and May 2022 were retrospectively analysed.Results:A total of 18 patients with HBV-related HCC were retrospectively analysed and divided into the LAPS group(n=9)and ALPPS group(n=9).Eight patients in the LAPS group and eight patients in the ALPPS group proceeded to a similar resection rate(88.9%vs 88.9%,P=1.000).The patients undergoing LAPS had a lower total comprehensive complication index than those undergoing ALPPS but there was not a significant different between the two groups(8.66 vs 35.87,P=0.054).The hypertrophy rate of FLR induced by ALPPS tended to be more rapid than that induced by LAPS(24.29 vs 13.17 mL/d,P=0.095).The 2-year recurrence-free survival(RFS)was 0%for ALPPS and 35.7%for LAPS(P=0.009),whereas the 2-year overall survival for ALPPS and LAPS was 33.3%and 100.0%(P=0.052),respectively.Conclusions:LAPS tended to induce lower morbidity and FLR hypertrophy more slowly than ALPPS,with a comparable resection rate and better long-term RFS in HBV-related HCC patients.

关 键 词：LAPS ALPPS hepatitis B virus hepatocellular carcinoma 

分 类 号：R735.7[医药卫生—肿瘤] R512.62[医药卫生—临床医学]