钙离子在牙釉质矿化中的作用  

The role of calcium ions in enamel mineralization

作　　者：李颖坤 董志恒[1] 高玉光[1] LI Yingkun;DONG Zhiheng;GAO Yuguang(Department of Stomatology,Binzhou Medical University Hospital,Binzhou 256603,Shandong,P.R.China)

机构地区：[1]滨州医学院附属医院口腔科,山东滨州256603

出　　处：《滨州医学院学报》2024年第1期76-80,共5页Journal of Binzhou Medical University

基　　金：国家自然科学基金(81870738)。

摘　　要：牙釉质的矿化形成是一个信号分子贯穿始终的过程,釉质矿化通过细胞内多种离子与信号通道的紧密调节和上皮与间充质的相互作用,最终使牙釉质成为人体中矿化程度最高、最硬的组织。Ca^(2+)作为细胞内重要的第二信使分子,在生物矿化中调节许多过程,其中就包括调节釉质蛋白的表达。在牙釉质的基本结构羟基磷灰石晶体中,约含有60%质量的Ca^(2+),由此可见Ca^(2+)是牙釉质的关键和必需成分。因此,Ca^(2+)的正常转运在牙釉质矿化过程中起着关键作用。The formation of enamel mineralization is a process in which signal molecules run through the whole process.Through the close regulation of various ions and signal channels in cells and the interaction between epithelium and mesenchymal,enamel mineralization ultimately makes enamel the hardest and most mineralized tissue in human body.As an important intracellular second messenger molecule,Ca^(2+)regulates many processes in biomineralization,including the expression of enamel proteins.Studies have shown that the basic structure of tooth enamel,hydroxyapatite crystals,contains about 60%of the mass of Ca^(2+),which shows that Ca^(2+)is a key and essential component of tooth enamel.Therefore,normal Ca^(2+)transport plays a key role in enamel mineralization.

关 键 词：CA^(2+) 牙釉质矿化 牙釉质 钙库操纵性钙离子内流通道 Cav1.2通道 

分 类 号：R783.1[医药卫生—口腔医学]