耐药菌的环境分布、传播及新型抗菌技术研究进展  

A review on environmental distribution, spread, and anti-bacterial technology of antibiotic-resistant bacteria

作　　者：欧阳富成 曹慧明 陈博磊 李准洁 李智 梁勇[2] OUYANG Fucheng;CAO Huiming;CHEN Bolei;LI Zhunjie;LI Zhi;LIANG Yong(The First School of Clinical Medicine,Southern Medical University,Guangzhou,510515,China;Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances,School of Environment and Health,Jianghan University,Wuhan,430056,China;Department of Orthopedics,General Hospital of Central Theater Command,Wuhan,430070,China)

机构地区：[1]南方医科大学第一临床医学院,广州510515 [2]持久性有毒污染物环境与健康危害湖北省重点实验室,环境与健康学院,江汉大学,武汉430056 [3]中部战区总医院骨科,武汉430070

出　　处：《环境化学》2024年第1期1-13,共13页Environmental Chemistry

基　　金：国家自然科学基金(22193051);军队后勤科研计划项目资助。

摘　　要：抗生素的广泛使用导致细菌耐药性增加、多重耐药菌菌群数量急剧增多,严重威胁着人类生命健康.环境中耐药菌(ARB)及耐药基因(ARGs)的存在给临床治疗耐药菌感染带来了巨大挑战.有关医院中常见耐药致病菌的研究已有很多,尚缺乏环境中耐药菌的分布、传播及新型耐药菌抗菌技术等的相关研究.本文综述了耐药菌的环境分布特征及其传播机制,概述了新型抗菌技术及其应用,最后展望了有关环境耐药菌研究的未来发展方向.The widespread use of antibiotics results in the increase of antibiotic-resistant bacteria(ARB)and their potential for drug resistant,which poses a serious threat to human health.The occurrence of ARB and antibiotic resistance genes(ARGs)in the environment presents a great challenge to the clinical treatment of antibiotic resistant bacteria infections.While great efforts have been made to study common drug-resistant pathogens in hospitals,there is still a lack of understanding regarding the distribution and spread of ARB in the environment.Furthermore,the development of new anti-bacterial technology is slow.This paper reviews the environmental distribution characteristics and spread mechanisms of ARB,summarizes the new anti-bacterial technology and its applications,and finally provides prospects for future research on ARB in the environment.

关 键 词：耐药菌 环境分布 传播 抗菌技术 展望 

分 类 号：X172[环境科学与工程—环境科学]