高危型人乳头瘤病毒基因亚型感染与宫颈病变的相关性研究  

Association between high-risk HPV genotype subtype infection and cervical lesions

作　　者：王敏 杨波 王娟 陈龙 买莉 王佳陪 WANG Min;YANG Bo;WANG Juan;CHEN Long;MAI Li;WANG Jiapei(Department of Pathology,Yinchuan Maternal and Children Health Care Hospital,Yinchuan 750001,China;Department of Gynecology,Yinchuan Maternal and Children Health Care Hospital,Yinchuan 750001,China)

机构地区：[1]宁夏银川市妇幼保健院病理科,宁夏银川750001 [2]宁夏银川市妇幼保健院妇科,宁夏银川750001

出　　处：《宁夏医学杂志》2024年第1期5-8,共4页Ningxia Medical Journal

摘　　要：目的 分析高危型人乳头瘤病毒(HR-HPV)基因亚型感染与宫颈病变的关系。方法 选取行HPV分型检测及活组织病理检查,符合标准的872例宫颈病变患者,分析HR-HPV单一感染型别、多重混合感染型别、亚型数与宫颈病变的发生及分布情况。结果 符合标准的872例宫颈病变患者,单一感染597例,占比68.46%,检出最高的5种基因亚型依次为16、52、58、18(33)、31,其中宫颈炎组检出前5种高危亚型依次为16、52、58、53、59;CIN1组检出前5种高危亚型依次为16、58、 52、18、31;CIN2及CIN3组检出前5种高危亚型依次为16、52、58、33、18,宫颈癌组以16为主,其次为33,单一感染中HPV16随病变程度的加重,感染率明显增高,4组比较差异有统计学意义(P<0.05)。多重感染275例,占比31.54%,检出最高的5种基因亚型依次为16、52、58、18、53,其中宫颈炎组检出前5种高危亚型依次为58、52、16、53、18;CIN1组检出前5种高危亚型依次为16、52、58、53、51;CIN2及CIN3组检出前5种高危亚型依次为16、52、 58、18、33,宫颈癌组主要为16,其次为18,多重感染中HPV16随病变程度的加重,感染率明显增高,4组比较差异有统计学意义(P<0.05)。结论 单一感染和多重感染检出最高的前3种亚型均为16、52、58,其中HPV16检出率与病变程度呈正相关,不同宫颈病变中单一感染高于多重感染,多重感染并不影响病变程度。Objective[JP+1]To analyze the association between high-risk human papillomavirus(HR-HPV)genotype infection and cervical lesions.Methods A total of 872 patients with cervical lesions who met the criteria for HPV typing and biopsy were selected.The HPV typing and biopsy,the occurrence and distribution of HR-HPV single infection type,multiple mixed infection type,number of subtypes and cervical lesions were analyzed.Results Among the 872 patients with cervical lesions who met the criteria were included in the study,597 cases(68.46%)were single-infected,and the five genotypes with the highest detection were 16,52,58,18(33),31,and the top five high-risk subtypes were 16,52,58,53 and 59 in the cervicitis group.The top five high-risk subtypes detected in the CIN 1 group were 16,58,52,18 and 31,and the top five high-risk subtypes detected in the CIN 2 and CIN 3 groups were 16,52,58,and 33,18,cervical cancer group was mainly 16 types,followed by 33 types,HPV16 type with the aggravation of lesion in a single infection,the infection rate increased significantly,the difference was statistically significant(P<0.05).There were 275 cases(31.54%)of multiple infection,and the five genotypes with the highest detection were 16,52,58,18 and 53,among which the top five high-risk subtypes detected in the cervicitis group were 58,52,16,53,18,the first five high-risk subtypes detected in the CIN 1 group were 16,52,58,53,and 51;the top five high-risk subtypes detected in the CIN 2 and CIN 3 groups were 16,52,58,18,33,and the cervical cancer group was mainly 16 types.It was followed by type 18,HPV16 type increased significantly with the aggravation of lesion degree in multiple infections(P<0.05).Conclusion The top three types with the highest detection of single infection and multiple infection are 16,52 and 58,among which the detection rate of HPV16 type is positively correlated with the degree of lesions,and the single infection is higher than that of mixed infection in different cervical lesions.

关 键 词：高危型HPV 单一感染 多重感染 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]